Browsing by Author "Dube, Admire"
Now showing items 1-11 of 11
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Comparative study on the topical and transdermal delivery of diclofenac incorporated in nano-emulsions, nano-emulgels, and a colloidal suspension
Dube, Admire; Louw, Estelle-Vionè; Liebenberg, Wilna (Springer, 2022)Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The ... -
The domestication of the African union model law on medical products regulation: perceived benefits, enabling factors, and challenges
Ncube, Bakani Mark; Dube, Admire; Ward, Kim (Frontiers Media, 2023)Introduction: In 2016, the African Union (AU) Model Law on Medical Products Regulation was endorsed by AU Heads of State and Government. The aims of the legislation include harmonisation of regulatory systems, increasing ... -
Establishment of the African Medicines Agency: Progress, challenges and regulatory readiness
Ncube, Bakani Mark; Dube, Admire; Ward, Kim (Springer Nature, 2021)Insufcient access to quality, safe, efcacious and afordable medical products in Africa has posed a signifcant challenge to public health for decades. In part, this is attributed to weak or absent policies and regulatory ... -
Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles
Khoza, Leon J.; Kumar, Pradeep; Dube, Admire (Elsevier, 2022)Tuberculosis (TB) remains one of the deadliest communicable dis- eases caused by Mycobacterium tuberculosis (Mtb) since its discovery in the 1880s (Cambau and Drancourt, 2014; Singh et al., 2020). Over 1 billion mortalities ... -
Medicines regulatory science expertise in Africa: workforce capacity development and harmonisation activities towards the establishment of the African medicines agency
Dube, Admire; Ncube, Bakani Mark; Ward, Kim (Adis, 2022)The medicines regulatory landscape in Africa is undergoing transformation with at least two countries having National Medicines Regulatory Authorities (NRAs) that operate at World Health Organization (WHO) maturity level ... -
Nanomedicines for infectious diseases
Dube, Admire (Springer Nature, 2019)Infectious diseases continue to pose a significant threat to global health. Over 200 infectious diseases are currently known to man. Fortunately, only a handful are responsible for significant morbidity and mortality. ... -
Permeation challenges of drugs for treatment of neurological tuberculosis and HIV and the application of magneto-electric nanoparticle drug delivery systems
Fisher, David W.; Tchoula Tchokonte, Moise B.; Dube, Admire; Mhambi, Sinaye (MDPI, 2021)The anatomical structure of the brain at the blood-brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Drug delivery facilitated by magneto-electric nanoparticles (MENs) ... -
A perspective on nanotechnology and covid-19 vaccine research and production in south africa
Egieyeh, Samuel; Dube, Admire (MDPI, 2021)Advances in nanotechnology have enabled the development of a new generation of vaccines, which are playing a critical role in the global control of the COVID-19 pandemic and the return to normalcy. Vaccine development ... -
Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier
Chigumira, Washington; Maposa, Prosper; Dube, Admire (Hindawi, 2015)Pralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and ... -
Situation analysis on the regulation of nanomedicines in Southern Africa
Mudyiwenyama, Linda G.; Khoza, Star; Dube, Admire (Frontiers Media, 2023)Medical products incorporating nanoparticle drug delivery systems (nanomedicines) are therapeutic or imaging agents, which comprise a delivery system within the nanometer size range (1 – 1000 nm). As medical products, ... -
Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin
Dube, Admire; Tshweu, Lesego L.; Shemis, Mohamed Abbas (Royal Society of Chemistry, 2020)Antibiotic resistance is increasing at such an alarming rate that it is now one of the greatest global health challenges. Undesirable toxic side-effects of the drugs lead to high rates of non-completion of treatment regimens ...