Browsing by Author "Henkel, R"
Now showing items 1-19 of 19
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Association among sperm chromatin condensation, sperm DNA fragmentation and 8-OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia
Hologlu, D; Gunes, S; Henkel, R (Wiley, 2021)The present study aimed to investigate the clinical role of standard sperm diagnosis parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed ... -
Association of XRCC1 and ERCC2 promoters’ methylation with chromatin condensation and sperm DNA fragmentation in idiopathic oligoasthenoteratozoospermic men
Henkel, R; Metin Mahmutoglu, A; Gunes, S (Blackwell Publishing Ltd, 2021)The aim of the study was to investigate whether the promoter methylation of XRCC1 and ERCC2 genes is associated with sperm DNA fragmentation and chromatin condensation in idiopathic oligoasthenoteratozoospermic men. This ... -
Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation
Henkel, R; Dutta, S; Agarwal, A (Blackwell Publishing Ltd, 2021)Male infertility has a complex etiology, and many times, the cause is unknown. While routine semen analysis provides an overview of basic semen parameters, such as sperm concentration, motility, viability and morphology, ... -
Diagnostic value of advanced semen analysis in evaluation of male infertility
Henkel, R; Barbarosie, C; Agarwal, A (Blackwell Publishing Ltd, 2021)Conventional semen analysis is the standard of care to initially evaluate the fertility status of a male patient. However, it has some limitations and among these are failure to correctly identify the aetiology underlying ... -
Diagnostic value of routine semen analysis in clinical andrology
Henkel, R; Baskaran, S; Finelli, R (Blackwell Publishing Ltd, 2021)Infertility is a major health issue affecting over 48.5 million couples around the world, with the male factor accounting for about 50% of the cases. The conventional semen analysis recommended by the World Health Organization ... -
Environmental contaminants and male infertility: Effects and mechanisms
Henkel, R; Selvaraju, V; Baskaran, S (Blackwell Publishing Ltd, 2021)The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. ... -
Etiologies of sperm DNA damage and its impact on male infertility
Henkel, R; Panner Selvam, M.K; Ambar, R.F (Blackwell Publishing Ltd, 2021)Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is considered the cornerstone of laboratory evaluation of male infertility, but it has its own drawbacks and fails to predict the ... -
Evaluation of seminal oxidation–reduction potential in male infertility
Henkel, R; Panner Selvam, M.K; Finelli, R (Blackwell Publishing Ltd, 2021)The role of oxidative stress in male infertility has been broadly recognised, and the search for a new marker to determine the redox environment in semen has gained considerable interest. Oxidation–reduction potential (ORP) ... -
Impact of body composition analysis on male sexual function: A metabolic age study
Henkel, R (Frontiers, 2023)Metabolic Age (MetAge) and body composition analysis may reflect an individual’s metabolic status, which is believed to influence male sexual and gonadal functions. Although erectile dysfunction (ED) and hypogonadism ... -
Male infertility
Agarwal, A; Baskaran, S; Henkel, R (Lancet Publishing Group, 2021)It is estimated that infertility affects 8–12% of couples globally, with a male factor being a primary or contributing cause in approximately 50% of couples. Causes of male subfertility vary highly, but can be related to ... -
Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men
Mahmutoglu, A; Dirie, S; Henkel, R (Wiley, 2021)Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), ... -
Protein profiling in unlocking the basis of varicocele-associated infertility
Henkel, R; Panner Selvam, M.K; Baskaran, S (Blackwell Publishing Ltd, 2021)Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in ... -
Proteomics and metabolomics — Current and future perspectives in clinical andrology
Henkel, R; Panner, Selvam M.K; Finelli, R (Blackwell Publishing Ltd, 2021)Proteomics and metabolomics are emerging as promising tools to investigate the molecular mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in regulating the molecular pathways ... -
Reactive oxygen species in male reproduction: A boon or a bane?
Henkel, R; Baskaran, S; Finelli, R (Blackwell Publishing Ltd, 2021)Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular metabolism. ROS play a crucial role in the physiological processes and signalling pathways associated with male fertility. At ... -
The role of infections and leukocytes in male infertility
Henkel, R; Offor, U; Fisher, D (Blackwell Publishing Ltd, 2021)Declining birth rates are one of the problems facing society today. Male counterparts are responsible for about half of the infertility cases, and genitourinary tract infections may play a contributing role in approximately ... -
A scientometric analysis of research publications on male infertility and assisted reproductive technology
Henkel, R; Agarwal, A; Panner Selvam, M.K (Blackwell Publishing Ltd, 2021)Assisted reproductive technologies (ART) are considered as one of the primary management options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male ... -
Total antioxidant capacity—Relevance, methods and clinical implications
Henkel, R; Gupta, S; Finelli, R (Blackwell Publishing Ltd, 2021)Oxidative stress is pre-empted by an adequate level of antioxidants, which scavenge oxidants when they are produced in excess by different sources, including leukocytes and immature spermatozoa. Enzymatic antioxidants, ... -
TUNEL assay—Standardized method for testing sperm DNA fragmentation
Henkel, R; Sharma, R; Iovine, C (Blackwell Publishing Ltd, 2021)Sperm DNA integrity is important for normal functions such as fertilization, implantation, pregnancy and fetal development. Sperm DNA fragmentation (SDF) is more common in infertile men and may be responsible for poor ... -
An update on the techniques used to measure oxidative stress in seminal plasma
Henkel, R; Robert, K.A; Sharma, R (Blackwell Publishing Ltd, 2021)Reactive oxygen species (ROS) are produced in significant amounts by spermatozoa and leucocytes. They are necessary to carry out various physiological functions such as sperm capacitation, hyperactivation, acrosome reaction, ...