Browsing by Author "Keyster, Marshall"
Now showing items 1-15 of 15
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Analytical studies of antimicrobial peptides as diagnostic biomarkers for the detection of bacterial and viral Pneumonia
Bakare, Olalekan Olanrewaju; Gokul, Arun; Keyster, Marshall (MDPI, 2022)Pneumonia remains one of the leading causes of infectious mortality and significant economic losses among our growing population. The lack of specific biomarkers for correct and timely diagnosis to detect patients’ status ... -
Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer
Bakare, Olalekan; Gokul, Arun; Keyster, Marshall (MDPI, 2021)The global increase in cancer mortality and economic losses necessitates the cautious quest for therapeutic agents with compensatory advantages over conventional therapies. Anticancer peptides (ACPs) are a subset of host ... -
Building HMM and molecular docking analysis for the sensitive detection of anti-viral pneumonia antimicrobial peptides (AMPs)
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Pretorius, Ashley (Nature Research, 2021)Pneumonia is the main reason for mortality among children under five years, causing 1.6 million deaths every year; late research has exhibited that mortality is increasing in the elderly. A few biomarkers used for its ... -
Capacity to control oxidative stress-induced caspase-like activity determines the level of tolerance to salt stress in two contrasting maize genotypes
Keyster, Marshall; Klein, Ashwil; Du Plessis, Morné; Jacobs, Alex; Kappo, Abidemi; Kocsy, Gábor; Galiba, Gábor; Ludidi, Ndiko (Springer, 2013)The response of two maize (Zea mays L.) genotypes, named GR (salt-tolerant) and SK (salt-sensitive), to salt stress (150 mM NaCl) was investigated under controlled environmental growth conditions. Genotype SK experienced ... -
Decoding heavy metal stress signalling in plants: Towards improved food security and safety
Keyster, Marshall; Niekerk, Lee Ann; Basson, Gerhard (MDPI, 2020)The mining of heavy metals from the environment leads to an increase in soil pollution, leading to the uptake of heavy metals into plant tissue. The build-up of toxic metals in plant cells often leads to cellular damage ... -
Efficient superoxide scavenging and metal immobilization in roots determines the level of tolerance to vanadium stress in two contrasting Brassica napus genotypes
Gokul, Arun; Cyster, Lilburne F.; Keyster, Marshall (Elsevier, 2018)Brassica napus also known as Rapeseed is a member of the Brassicaceae family which is mainly cultivated for its oil-rich seeds. Indeed, B. napus is ranked the third-largest source of vegetable oil in the world. Brassica ... -
Exogenous p-coumaric acid improves salvia hispanica l. Seedling shoot growth
Nkomo, Mbukeni; Gokul, Arun; Keyster, Marshall; Klein, Ashwil (MDPI Open Access Journals, 2019)p-Coumaric acid (p-CA) belongs to a family of natural esters of hydroxycinnamic acid compounds that have been shown to modulate plant growth and metabolism. In this study, we investigated the effect of exogenous p-CA on ... -
Identification of biomarkers for the accurate and sensitive diagnosis of three bacterial pneumonia pathogens using in silico approaches
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Pretorius, Ashley (Springer Nature, 2020): Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A few ... -
Inhibition of NOS- like activity in maize alters the expression of genes involved in H2O2 scavenging and glycine betaine biosynthesis
Phillips, Kyle; Majola, Anelisa; Gokul, Arun; Keyster, Marshall; Ludidi, Ndiko; Egbichi, Ifeanyi (Nature Publishing Group, 2018)Nitric oxide synthase-like activity contributes to the production of nitric oxide in plants, which controls plant responses to stress. This study investigates if changes in ascorbate peroxidase enzymatic activity and ... -
Modulation of antioxidant enzyme activities and metabolites ratios by nitric oxide in short-term salt stressed soybean root nodules
Egbichi, I.; Keyster, Marshall; Jacobs, Alex; Klein, Ashwil; Ludidi, Ndiko (Elsevier, 2013)Several abiotic factors cause molecular damage to plants either directly or through the accumulation of reactive oxygen species such as hydrogen peroxide (H2O2). We investigated if application of nitric oxide (NO) donor ... -
Nitric oxide (NO) regulates the expression of single-domain cystatins in glycine max (soybean)
Keyster, Marshall; Adams, Ruqaiyah; Klein, Ashwil; Ludidi, Ndiko (Southern Cross Publishing, 2013)Plant cystatins inhibit cysteine proteases and are important in regulating plant development and plant responses to biotic and abiotic stress. Furthermore, nitric oxide plays a signaling role in regulating plant responses ... -
Nitric oxide affects salt-induced changes in free amino acid levels in maize
Boldizsár, Ákos; Simon-Sarkadi, Livia; Keyster, Marshall; Ludidi, Ndiko (Elsevier, 2013)It was assumed that salt-induced redox changes affect amino acid metabolism in maize (Zea mays L.), and this influence may be modified by NO. The applied NaCl treatment reduced the fresh weight of shoots and roots. This ... -
Response of soybean nodules to exogenously applied caffeic acid during NaCl-induced salinity
Klein, Ashwil; Keyster, Marshall; Ludidi, Ndiko N. (Elsevier, 2015)affeic acid acts as an antioxidant to scavenge reactive oxygen species, but its influence on plant responses to abi- otic stresses is only partially understood. Here, we investigated the influence of exogenously applied ... -
Salinity induced leaf anatomical responses and chemical composition in tetragonia decumbens mill.: An underutilized edible halophyte in South Africa
Sogoni, Avela; Keyster, Marshall; Jimoh, Muhali (Pleiades Publishing, 2023)Abstract: Tetragonia decumbens Mill. has recently been reported to withstand the adverse effect of salinity. However, its leaf anatomical responses are poorly understood since previous studies were focused on basic ... -
Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Fadaka, Adewale Oluwaseun (Dove Medical Press, 2020)Several studies have explored the design of antimicrobial peptides (AMPs) for the development of therapeutic and diagnostic molecules for the treatment and identification of pathogenic diseases as well as cancer. Human ...