Browsing by Author "Tiffin, Nicki"
Now showing items 1-9 of 9
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Blood pressure gradients and cardiovascular risk factors in urban and rural populations in Abia State South Eastern Nigeria using the WHO STEPwise approach
Okpechi, Ikechi Gareth; Chukwuonye, Innocent Ijezie; Tiffin, Nicki; Madukwe, Okechukwu Ojoemelam; Onyeonoro, Ugochukwu Uchenna; Umeizudike, Theophilus Ifeanyichukwu; Ogah, Okechukwu Samuel; Onyeonoro, Ugochukwu Uchenna (Public Library of Science, 2013)Background: Developing countries of sub-Saharan Africa (SSA) face a double burden of non-communicable diseases (NCDs) and communicable diseases. As high blood pressure (BP) is a common global cardiovascular (CV) disorder ... -
Covid-19 among adults living with HIV: Correlates of mortality among public sector healthcare users in Western Cape, South Africa
Kassanjee, Reshma; Davies, Mary-Ann; Tiffin, Nicki (Wiley, 2023)Introduction: While a large proportion of people with HIV (PWH) have experienced SARS-CoV-2 infections, there is uncertainty about the role of HIV disease severity on COVID-19 outcomes, especially in lower-income settings. ... -
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus
Tiffin, Nicki; Adeyemo, Adebowale A.; Okpechi, Ikechi (Biomed Central, 2013)Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can ... -
An e-consent framework for tiered informed consent for human genomic research in the global south, implemented as a REDCap template
Tamuhla, Tsaone; Tiffin, Nicki; Allie, Tarryn (BMC Medics, 2022)Research involving human participants requires their consent, and it is common practice to capture consent information on paper and store those hard copies, presenting issues such as long-term storage requirements, ... -
Ethical and legal implications of whole genome and whole exome sequencing in African populations
Wright, Galen E.B.; Koornhof, Pieter G.J.; Adeyemo, Adebowale A.; Tiffin, Nicki (BioMed Central, 2013)BACKGROUND: Rapid advances in high throughput genomic technologies and next generation sequencing are making medical genomic research more readily accessible and affordable, including the sequencing of patient and control ... -
How to use relevant data for maximal benefit with minimal risk: Digital health data governance to protect vulnerable populations in low-income and middle- income countries
Tiffin, Nicki; George, Asha; LeFevre, Amnesty Elizabeth (BMJ Global Health, 2019)Globally, the volume of private and personal digital data has massively increased, accompanied by rapid expansion in the generation and use of digital health data. These technological advances promise increased opportunity for ... -
Lenses and levels: the why, what and how of measuring health system drivers of women’s, children’s and adolescents’ health with a governance focus
George, Asha; LeFevre, Amnesty Elizabeth; Jacobs, Tanya; Kinney, Mary; Buse, Kent; Chopra, Mickey; Daelmans, Bernadette; Haakenstad, Annie; Huicho, Luis; Khosla, Rajat; Rasanathan, Kumanan; Sanders, David; Singh, Neha S; Tiffin, Nicki; Ved, Rajani; Zaidi, Shehla Abbas; Schneider, Helen (BMJ, 2019)Health systems are critical for health outcomes as they underpin intervention coverage and quality, promote users’ rights and intervene on the social determinants of health. Governance is essential for health system ... -
A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without
Kroger, Wendy; Mapiye, Darlington; Entfellner, Jean-Baka Domelevo; Tiffin, Nicki (BioMed Central, 2017)BACKGROUND: Systemic Lupus Erythematosus (SLE) is a complex, multi-systemic, autoimmune disease for which the underlying aetiological mechanisms are poorly understood. The genetic and molecular processes underlying ... -
Record linkage for routinely collected health data in an African health information exchange
Mutemaringa, Themba; Heekes, Alexa; Tiffin, Nicki (Swansea University, 2023)The Patient Master Index (PMI) plays an important role in management of patient information and epidemiological research, and the availability of unique patient identifiers improves the accuracy when linking patient ...