Browsing Faculty of Natural Sciences by Subject "Natural products"
Now showing items 1-9 of 9
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Alkaloids: Therapeutic Potential against Human Coronaviruses
(MPDI, 2020)Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity ... -
Antibacterial activities of bacteria isolated from the marine sponges Isodictya compressa and Higginsia bidentifera collected from Algoa Bay, South Africa
(MDPI AG, 2017)Due to the rise inmulti-drug resistant pathogens and other diseases, there is renewed interest in marine sponge endosymbionts as a rich source of natural products (NPs). The South African marine environment is rich in ... -
Cheminformatic profiling and hit prioritization of natural products with activities against Methicillin-Resistant Staphylococcus Aureus (MRSA)
(MPDI, 2021)Several natural products (NPs) have displayed varying in vitro activities against methicillinresistant Staphylococcus aureus (MRSA). However, few of these compounds have not been developed into potential antimicrobial ... -
Exploration of scaffolds from natural products with antiplasmodial activities, currently registered antimalarial drugs and public malarial screen data
(MDPI, 2016)In light of current resistance to antimalarial drugs, there is a need to discover new classes of antimalarial agents with unique mechanisms of action. Identification of unique scaffolds from natural products with in vitro ... -
Fractions of Hoslundia opposita Vahl and hoslundin induced apoptosis in human cancer cells via mitochondrial-dependent reactive oxygen species (ROS) generation
(Elsevier, 2022)ancer remains one of the leading causalities of several morbidity and mortality with negative impact on global economy due to low workforce and management/treatment cost. A number of conventional therapies have been ... -
Gene expression modulation of apoptotic and oestrogen receptor alpha genes by active fractions of selected Nigerian plants on cervical cancer cell line (hela)
(University of Benin, 2021)The roles of natural product in drug discovery and development cannot be over emphasised. It plays a vital role in human therapy and gives a better understanding on the cellular pathways.This study investigated the ... -
Green synthesized saunps as a potential delivery platform for cytotoxic alkaloids
(MDPI, 2023)The use of natural products as chemotherapeutic agents is well established. However, many are associated with undesirable side effects, including high toxicity and instability. Previous reports on the cytotoxic activity ... -
Pineapple stem-derived bromelain based priming improves pepper seed protein reserve mobilization, germination, emergence and plant growth
(Springer, 2021)Pepper seeds are slow to germinate and emergence is often non-uniform and incomplete, reducing gains from this cash crop. This study investigated the effects of pineapple stem- derived protease (stem bromelain) based priming ... -
Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach
(Public Library of Science, 2018)In view of the vast number of natural products with potential antiplasmodial bioactivity and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from previous antiplasmodial bioassays and ...