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Gonad differentiation in zebrafish is regulated by the canonical Wnt signalling pathway
(Society for the Study of Reproduction, 2014)
Zebrafish males undergo a ‘‘juvenile ovary-to-testis’’ gonadal transformation process. Several genes, including nuclear receptor subfamily 5, group A (nr5a) and anti-Mu¨ llerian hormone (amh), and pathways such as Tp53-mediated ...
DAMPD: a manually curated antimicrobial peptide database
(Oxford University Press, 2012)
The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates ...
Information security at South African universities-Implications for biomedical research
(Oxford University Press, 2020)
In South Africa, a similar regulation strategy to
the European Union General Data Protection
Regulation, called the Protection of Personal
Information Act (No 4 of 2013) (POPIA), will be
implemented, with a view to ...
Cheminformatic Characterization of Natural Antimicrob al Products for the Development of New Lead Compounds
(MDPI, 2021)
The growing antimicrobial resistance (AMR) of pathogenic organisms to currently pre- scribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the ...
Cheminformatic profiling and hit prioritization of natural products with activities against Methicillin-Resistant Staphylococcus Aureus (MRSA)
(MPDI, 2021)
Several natural products (NPs) have displayed varying in vitro activities against methicillinresistant Staphylococcus aureus (MRSA). However, few of these compounds have not been developed
into potential antimicrobial ...
Cheminformatic Profiling and Hit Prioritization of Natural Products with Activities against Methicillin-Resistant Staphylococcus aureus (MRSA)
(Molecules, 2021-06)
Several natural products (NPs) have displayed varying in vitro activities against methicillin-resistant Staphylococcus aureus (MRSA). However, few of these compounds have not been developed into potential antimicrobial ...
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
(Oxford University Press, 2018)
Triplet amino acids have successfully been included in feature selection to predict
human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is
curtailed due to experimental data not being ...
In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)
(Public Library of Science, 2021)
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug
target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis
growth. It is conserved between mycobacterium ...
MicroRNA profile of Hermetia illucens (black soldier fly) and its implications on mass rearing
(PloS one, 2022)
The growing demands on protein producers and the dwindling available resources have made Hermetia illucens (the black soldier fly, BSF) an economically important species. Insights into the genome of this insect will better ...
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
(American Association for the Advancement of Science, 2022)
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the ...