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dc.contributor.authorMatobole, Relebohile Matthew
dc.contributor.authorvan Zyl, Leonardo Joaquim
dc.contributor.authorParker-Nance, Shirley
dc.contributor.authorDavies-Coleman, Michael T.
dc.contributor.authorTrindade, Marla
dc.date.accessioned2017-03-20T15:48:23Z
dc.date.available2017-03-20T15:48:23Z
dc.date.issued2017
dc.identifier.citationMatobole, R. M. (2017). Antibacterial activities of bacteria isolated from the marine sponges Isodictya compressa and Higginsia bidentifera collected from Algoa Bay, South Africa. Marine Drugs, 15(2): 47en_US
dc.identifier.issn1660-3397
dc.identifier.urihttp://dx.doi.org/10.3390/md15020047
dc.identifier.urihttp://hdl.handle.net/10566/2688
dc.description.abstractDue to the rise inmulti-drug resistant pathogens and other diseases, there is renewed interest in marine sponge endosymbionts as a rich source of natural products (NPs). The South African marine environment is rich in marine biota that remains largely unexplored and may represent an important source for the discovery of novel NPs.We first investigated the bacterial diversity associated with five South African marine sponges, whose microbial populations had not previously been investigated, and select the two sponges (Isodictya compressa and Higginsia bidentifera) with highest species richness to culture bacteria. By employing 33 different growth conditions 415 sponge-associated bacterial isolates were cultured and screened for antibacterial activity. Thirty-five isolates showed antibacterial activity, twelve of which exhibited activity against the multi-drug resistant Escherichia coli 1699, implying that some of the bioactive compounds could be novel. Genome sequencing of two of these isolates confirmed that they harbour uncharacterized biosynthetic pathways that may encode novel chemical structures.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
dc.subjectIsodictya compressaen_US
dc.subjectHigginsia bidentiferaen_US
dc.subjectNatural productsen_US
dc.subjectMarine spongeen_US
dc.subjectAntimicrobialen_US
dc.titleAntibacterial activities of bacteria isolated from the marine sponges Isodictya compressa and Higginsia bidentifera collected from Algoa Bay, South Africaen_US
dc.typeArticleen_US
dc.privacy.showsubmitterFALSE
dc.status.ispeerreviewedTRUE
dc.description.accreditationISIen_US


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