Show simple item record

dc.contributor.authorLewis, Sheena E.M.
dc.contributor.authorAitken, R. John
dc.contributor.authorConner, Sarah J.
dc.contributor.authorDe Iuliis, Geoffry
dc.contributor.authorEvenson, Donald P.
dc.contributor.authorHenkel, Ralf
dc.contributor.authorGiwercman, Aleksander
dc.contributor.authorGharagozloo, Parviz
dc.date.accessioned2017-09-12T12:54:34Z
dc.date.available2017-09-12T12:54:34Z
dc.date.issued2013
dc.identifier.citationLewis, S.E.M. et al. (2013). The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment. Reproductive BioMedicine Online, 2: 327 - 337en_US
dc.identifier.issn1472-6483
dc.identifier.urihttp://dx.doi.org/10.1016/j.rbmo.2013.06.014
dc.identifier.urihttp://hdl.handle.net/10566/3191
dc.description.abstractSperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological significance of DNA damage in the male germ line is considered. Finally, as sperm DNA damage is often the result of oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy in the clinical management of this condition is discussed. DNA damage in human 1472-6483/$en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1016/j.rbmo.2013.06.014
dc.subjectAntioxidant therapyen_US
dc.subjectAssisted reproductionen_US
dc.subjectDNA fragmentationen_US
dc.subjectMale infertilityen_US
dc.subjectOxidized basesen_US
dc.subjectSpermatozoaen_US
dc.titleThe impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatmenten_US
dc.typeArticleen_US
dc.privacy.showsubmitterFALSE
dc.status.ispeerreviewedTRUE
dc.description.accreditationWeb of Science


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record