Library Portal | UWC Portal
    • Login
    Contact Us | Quick Submission Guide | About Us | FAQs | Login
    View Item 
    •   Repository Home
    • Faculty of Natural Sciences
    • Statistics and Population Studies
    • Research Articles (Statistics & Population Studies)
    • View Item
    •   Repository Home
    • Faculty of Natural Sciences
    • Statistics and Population Studies
    • Research Articles (Statistics & Population Studies)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease

    Thumbnail
    View/Open
    Salie_Associations-between_2013_.pdf (1.669Mb)
    Date
    2013
    Author
    Salie, Muneeb
    van der Merwe, Lize
    Möller, Marlo
    Daya, Michelle
    van der Spuy, Gian D.
    van Helden, Paul D.
    Martin, Maureen P.
    Gao, Xiao-jiang
    Warren, Robin M.
    Carrington, Mary
    Hoal, Eileen G.
    Metadata
    Show full item record
    Abstract
    BACKGROUND. The development of active tuberculosis disease has been shown to be multifactorial. Interactions between host and bacterial genotype may influence disease outcome, with some studies indicating the adaptation of M. tuberculosis strains to specific human populations. Here we investigate the role of the human leukocyte antigen (HLA) class I genes in this biological process. METHODS. Three hundred patients with tuberculosis from South Africa were typed for their HLA class I alleles by direct sequencing. Mycobacterium tuberculosis genotype classification was done by IS6110 restriction fragment length polymorphism genotyping and spoligotyping. RESULTS. We showed that Beijing strain occurred more frequently in individuals with multiple disease episodes (P < .001) with the HLA-B27 allele lowering the odds of having an additional episode (odds ratio, 0.21; P = .006). Associations were also identified for specific HLA types and disease caused by the Beijing, LAM, LCC, and Quebec strains. HLA types were also associated with disease caused by strains from the Euro-American or East Asian lineages, and the frequencies of these alleles in their sympatric human populations identified potential coevolutionary events between host and pathogen. CONCLUSIONS. This is the first report of the association of human HLA types and M. tuberculosis strain genotype, highlighting that both host and pathogen genetics need to be taken into consideration when studying tuberculosis disease development.
    URI
    http://dx.doi.org/10.1093/infdis/jit443
    http://hdl.handle.net/10566/3403
    Collections
    • Research Articles (Statistics & Population Studies) [112]

    DSpace 5.5 | Ubuntu 14.04 | Copyright © University of the Western Cape
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace 5.5 | Ubuntu 14.04 | Copyright © University of the Western Cape
    Contact Us | Send Feedback
    Theme by 
    @mire NV