Browsing Research Articles (Biotechnology) by Author "Meyer, Mervin"
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Antibacterial activity of rationally designed antimicrobial peptides
Tincho, Marius B.; Morris, Thureyah; Meyer, Mervin (Hindawi, 2020)Many infectious diseases are still prevalent in the world’s populations since no effective treatments are available to eradicate them. e reasons may either be the antibiotic resistance towards the available therapeutic ... -
Antibacterial activity of rationally designed antimicrobial peptides.
Morris, Thureyah; Tincho, Marius Belmondo; Meyer, Mervin (Hindawi, 2020)Many infectious diseases are still prevalent in the world’s populations since no effective treatments are available to eradicate them. e reasons may either be the antibiotic resistance towards the available therapeutic ... -
The antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticles
Tyavambiza, Caroline; Meyer, Mervin; Madiehe, Abram Madimabe (MDPI, 2022)The synthesis of silver nanoparticles using biogenic methods, particularly plants, has led to the discovery of several effective nanoparticles. In many instances, plant-derived silver nanoparticles have been shown to ... -
Flavonoid and phenolic acid profiles of dehulled and whole vigna subterranea (l.) Verdc seeds commonly consumed in South Africa
Okafor, Jane N. C.; Meyer, Mervin; Roes-Hill, Marilize Le (MDPI, 2022)Bambara groundnut (BGN) is an underexploited crop with a rich nutrient content and is used in traditional medicine, but limited information is available on the quantitative characterization of its flavonoids and phenolic ... -
Gold nanoparticles synthesized using extracts of cyclopia intermedia, commonly known as honeybush, amplify the cytotoxic effects of doxorubicin
Sibuyi, Nicole Remaliah Samantha; Aboyewa, Jumoke A.; Meyer, Mervin (MPDI, 2021)Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have ... -
Green synthesis of metallic nanoparticles using some selected medicinal plants from Southern Africa and their biological applications
Aboyewa, Jumoke A.; Sibuyi, Nicole R. S.; Meyer, Mervin (MPDI, 2021)The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ... -
Green synthesis of metallic nanoparticles using some selected medicinal plants from southern africa and their biological applications
Sibuyi, Nicole Remaliah Samantha; Meyer, Mervin; Aboyewa, J.A.; Oguntibeju, O.O. (MDPI, 2021)The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ... -
In vitro Antidiabetic and Antioxidant effects of different extracts of Catharanthus roseus and its indole alkaloid, vindoline
Meyer, Mervin; Goboza, Mediline; Aboua, Yapo Guillaume (MPDI, 2020)The Catharanthus roseus plant has been used traditionally to treat diabetes mellitus. Scientific evidence supporting the antidiabetic effects of this plant’s active ingredient-vindoline has not been fully evaluated. In ... -
Inhibition of bacteria associated with wound infection by biocompatible green synthesized gold nanoparticles from South African plant extracts
Elbagory, Abdulrahman M.; Meyer, Mervin; Cupido, Christopher N.; Hussein, Ahmed A. (MDPI, 2017)Unlike conventional physical and chemical methods, the biogenic synthesis of gold nanoparticles (GNPs) is considered a green and non-toxic approach to produce biocompatible GNPs that can be utilized in various biomedical ... -
Large Scale Screening of Southern African Plant Extracts for the Green Synthesis of Gold Nanoparticles Using Microtitre-Plate Method
Elbagory, Abdulrahman, M; Cupido, Christopher, N; Meyer, Mervin (Molecules, 2016-11)The preparation of gold nanoparticles (AuNPs) involves a variety of chemical and physical methods. These methods use toxic and environmentally harmful chemicals. Consequently, the synthesis of AuNPs using green chemistry ... -
A low-cost flow cytometric assay for the detection and quantification of apoptosis using an anionic halogenated fluorescein dye
Meyer, Mervin; Essack, Magbubah; Kanyanda, Stonard (Future Science Group, 2008)We describe here a technical improvement of an established colorimetric method used to detect and measure the occurrence of apoptosis in mammalian cells during in vitro cell culture. This assay uses an anionic halogenated ... -
Molecular application of aptamers in the diagnosis and treatment of cancer and communicable diseases
Molefe, Philisiwe Fortunate; Masamba, Priscilla; Oyinloye, Babatunji Emmanuel; Mbatha, Londiwe Simphiwe; Meyer, Mervin; Kappo, Abidemi Paul (MDPI, 2018)Cancer and infectious diseases such as Ebola, HIV, tuberculosis, Zika, hepatitis, measles and human schistosomiasis are serious global health hazards. The increasing annual morbidities and mortalities of these diseases ... -
Nanotechnology-based delivery systems for antimicrobial peptides
Adewale, Oluwaseun Fadaka; Sibuyi, Nicole Remaliah Samantha; Madiehe, Abram Madimabe; Meyer, Mervin (MDPI, 2021)Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides ... -
Nanotechnology-based strategies for effective and rapid detection of sars-cov-2
Moabelo, Koena L; Martin, Darius R; Fadaka, Adewale O; Sibuyi, Nicole R. S.; Meyer, Mervin (MDPI, 2021)The coronavirus disease 2019 (COVID-19) pandemic has gained worldwide attention and has prompted the development of innovative diagnostics, therapeutics, and vaccines to mitigate the pandemic. Diagnostic methods based ... -
One-pot synthesis and characterization of InP/ZnSe semiconductor nanocrystals
Mushonga, Paul; Onani, Martin O.; Madiehe, Abram M.; Meyer, Mervin (Elsevier, 2013)We report on the one-pot synthesis of InP/ZnSe quantum dots (QDs) using a precursor-based colloidal synthesis in a noncoordinating solvent environment. The structural and optical studies were carried out on the as-prepared ... -
Phenolic content, antioxidant, cytotoxic and antiproliferative effects of fractions of Vigna subterraenea (L.) verdc from Mpumalanga, South Africa
Okafor, Jane N.C.; Rautenbauch, Fanie; Meyer, Mervin (Elsevier, 2021)Consistent intake of legumes has been correlated with decreased possibility of developing colorectal cancer (CRC) due to the content of some phytochemicals like polyphenols. Bambara groundnut (BGN) is an underutilized ... -
Reports of plant-derived nanoparticles for prostate cancer therapy
Elbagory, Abdulrahman M; Hull, Rodney; Meyer, Mervin; Dlamini, Zodwa (MDPI, 2023)Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation of these ... -
Reports of plant-derived nanoparticles for prostate cancer therapy
Elbagory, Abdulrahman M.; Hull, Rodney; Meyer, Mervin (MDPI, 2023)Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation of ... -
Reports of Plant-Derived Nanoparticles for Prostate Cancer Therapy
Elbagory, Abdulrahman M.; Meyer, Mervin; Hull, Rodney; Dlamini, Zodwa (Plants, 2023)Background: Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation ... -
Synthesis and cytotoxic evaluation of gum arabic surface modified cadmium telluride quantum dots
Edwina, Uzunuigbe O; Kiplagat, Ayabei; Sibuyi, Nicole R. S.; Meyer, Mervin; Kappo, Abidemi Paul; Onani, Martin O (American Scientific Publishers, 2020)Water-soluble cadmium telluride (CdTe) quantum dots (QDs) were capped with gum Arabic (GA) is a non-toxic, water-soluble glycoprotein polymer commonly used in the food and pharmaceutical industries. The GA was used to ...