Deletion of IL-4Rα signalling on B cells limits hyperresponsiveness depending on antigen-load.
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B cells play an important role in allergies through secretion of IgE. Interleukin 4 50 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine production, IgE 51 secretion and airway hyperresponsiveness (AHR). IL-4 activation of B cells is essential for 52 class-switching and contributes to the induction of B effector 2 (Be2) cells. The role of Be2 53 cells and signalling via IL-4Rα in B cells is not clearly defined.