Recent Submissions

  • Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing 

    Bansode, Vijay; McCormack, Grace P.; Shrestha, Ram K.; Travers, Simon A.; Crampin, Amelia C.; Ngwira, Bagrey; French, Neil; Glynn, Judith R. (BioMed Central -The Open Access Publisher, 2013)
    BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary ...
  • Avihepadnavirus diversity in parrots is comparable to that found amongst all other avian species 

    Piasecki, Tomasz; Harkins, Gordon William; Chrzastek, Klaudia; Julian, Laurel; Martin, Darren Patrick; Varsani, Arvind (Elsevier, 2013)
    Avihepadna viruses have previously been isolated from various species of duck ,goose, stork, heron and crane. Recently the first parrot avihepadna virus was isolated from a Ring-necked Parakeet in Poland. In this study, ...
  • The influence f N-linked Glycans on the Molecular Dynamics of the HIV-1 gp120 V3 Loop 

    Wood, Natasha T.; Fadda, Elisa; Travers, Simon A.; Davis, Robert; Grant, Oliver C.; Martin, Joanne C.; Woods, Robert J. (Public Library of Science, 2013)
    N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising ...
  • Evidence of pervasive biologically functional secondary structures within the Genomes of Eukaryotic Single-Stranded DNA Viruses 

    Muhire, Brejnev Muhizi; Golden, Michael; Tanov, Emil Pavlov; Harkins, Gordon William; Murrell, Ben; Lefeuvre, Pierre; Lett, Jean-Michel; Gray, Alistair; Poon, Art Y. F.; Ngandu, Nobubelo Kwanele; Semegni, Yves; Monjane, Adérito Luis; Varsani, Arvind; Shepherd, Dionne Natalie; Martin, Darren Patrick (American Society for Microbiology, 2013)
    Single-stranded DNA (ssDNA) viruses have genomes that are potentially capable of forming complex secondary structures through Watson-Crick base pairing between their constituent nucleotides. A few of the structural elements ...
  • Genome sequence of the tsetse fly (glossina morsitans): vector of African trypanosomiasis 

    Christoffels, Alan; Obiero, George F.; Harkins, Gordon (American Association for the Advancement of Science, 2014)
    Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between ...
  • Selecting an appropriate method for expressing S locus F-box-S2 recombinant protein 

    Ashkani, Jahanshah; Rees, Jasper G. (Elsevier, 2017)
    A single locus (S locus) including at least two linked genes (female and male determinants) genetically controls the gametophytic self-incompatibility (GSI) in apple, which has evolved to avoid self-fertilization. There ...
  • Virome assembly and annotation: A surprise in the Namib Desert 

    Hesse, Uljana; Van Heusden, Peter; Kirby, Bronwyn; Olonade, Israel; van Zyl, Leonardo Joaquim; Trindade, Marla (Frontiers Research Foundation, 2017)
    Sequencing, assembly, and annotation of environmental virome samples is challenging. Methodological biases and differences in species abundance result in fragmentary read coverage; sequence reconstruction is further ...
  • Blood pressure gradients and cardiovascular risk factors in urban and rural populations in Abia State South Eastern Nigeria using the WHO STEPwise approach 

    Okpechi, Ikechi Gareth; Chukwuonye, Innocent Ijezie; Tiffin, Nicki; Madukwe, Okechukwu Ojoemelam; Onyeonoro, Ugochukwu Uchenna; Umeizudike, Theophilus Ifeanyichukwu; Ogah, Okechukwu Samuel; Onyeonoro, Ugochukwu Uchenna (Public Library of Science, 2013)
    Background: Developing countries of sub-Saharan Africa (SSA) face a double burden of non-communicable diseases (NCDs) and communicable diseases. As high blood pressure (BP) is a common global cardiovascular (CV) disorder ...
  • Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens 

    Van Zyl, Gert U.; Liu, Tommy F.; Claassen, Mathilda; Engelbrecht, Susan; de Oliveira, Tulio; Preiser, Wolfgang; Wood, Natasha T.; Travers, Simon; Shafer, Robert W. (University of the Western CapePublic Library of Science -- PLoS, 2013)
    South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We ...
  • A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus 

    Tiffin, Nicki; Adeyemo, Adebowale A.; Okpechi, Ikechi (Biomed Central, 2013)
    Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can ...
  • The Influence of N-Linked Glycans on the MolecularDynamics of the HIV-1 gp120 V3 Loop 

    Wood, Natasha T.; Fadda, Elisa; Davis, Robert; Grant, Oliver C.; Martin, Joanne C.; Woods, Robert J.; Travers, Simon A. (PLoS ONE, 2013)
    N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising ...
  • Opportunities in Africa for training in genome science 

    Masiga, Daniel K.; Isokpehi, Raphael D. (Academic Journals, 2004)
    Genome science is a new type of biology that unites genetics, molecular biology, computational biology and bioinformatics. The availability of the human genome sequence, as well as the genome sequences of several other ...
  • Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding 

    Vij, Shubha; Van Heusden, Peter; Christoffels, Alan; Mbandi, Stanley K.; Mwangi, Sarah (Public Library of Science, 2016)
    We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical and genetic mapping along with shared ...
  • Database for exploration of functional context of genes implicated in ovarian cancer 

    Kaur, Mandeer; Radovanovic, Aleksander; Essack, Magbubah; Schaefer, Ulf; Maqungo, Monique; Kibler, Tracey; Schmeier, Sebastian; Christoffels, Alan; Narasimhan, Kothandaraman; Choolani, Mahesh; Bajic, Vladimir B. (Oxford Journals, 2009)
    Ovarian cancer (OC) is becoming the most common gynecological cancer in developed countries and the most lethal gynecological malignancy. It is also the fifth leading cause of all cancer-related deaths in women. The ...
  • DDPC: Dragon database of genes associated with prostate cancer 

    Maqungo, Monique; Kaur, Mandeep; Kwofie, Samuel K.; Radovanovic, Aleksander; Schaefer, Ulf; Schmeier, Sebastian; Oppon, Ekow; Christoffels, Alan; Bajic, Vladimir B. (Oxford Journals, 2011)
    Prostate cancer (PC) is one of the most commonly diagnosed cancers in men. PC is relatively difficult to diagnose due to a lack of clear early symptoms. Extensive research of PC has led to the availability of a large amount ...
  • DDESC: Dragon database for exploration of sodium channels in human 

    Sagar, Sunil; Kaur, Mandeep; Dawe, Adam; Seshadri, Sundararajan V.; Christoffels, Alan; Schaefer, Ulf; Radovanovic, Aleksander; Bajic, Vladimir B. (BMC Cancer, 2008)
    Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic ...
  • DDEC: Dragon databaseof genes implicated in esophageal cancer 

    Essack, Magbubah; Radovanovic, Aleksander; Schaefer, Ulf; Schmeier, Sebastian; Seshadri, Sundararajan V.; Christoffels, Alan; Kaur, Mandeep; Bajic, Vladimir B. (BioMed Central, 2009)
    Esophageal cancer ranks eighth in order of cancer occurrence. Its lethality primarily stems from inability to detect the disease during the early organ-confined stage and the lack of effective therapies for advanced-stage ...
  • Self-similarity of human protein interaction networks: a novel strategy of distinguishing proteins 

    Fadhal, Emad; Gamieldien, Junaid; Mwambene, Eric (2015)
    The successful determination of reliable protein interaction networks (PINs) in several species in the post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of such networks. ...
  • Taste and odorant receptors of the coelecanth- a gene repertoire in transition 

    Picone, Barbara; Hesse, Uljana; Panji, Sumir; Van Heusden, Peter; Jonas, Mario; Christoffels, Alan (Wiley, 2014)
    G-protein coupled chemosensory receptors (GPCR-CRs) aid in the perception of odors and tastes in vertebrates. So far, six GPCR-CR families have been identified that are conserved in most vertebrate species. Phylogenetic ...
  • Transcriptomic analysis reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain 

    Sreenivasan, Rajini; Cai, Minnie; Bartfai, Richard; Wang, Xingang; Orban, Laszlo; Christoffels, Alan (Plosone, 2008)
    Our knowledge on zebrafish reproduction is very limited. We generated a gonad-derived cDNA microarray from zebrafish and used it to analyze large-scale gene expression profiles in adult gonads and other organs. We have ...

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