Now showing items 1-6 of 6

    • The African Coelecanth genome provides insights into tetrapod evolution 

      Christoffels, Alan; Hesse, Uljana; Gamieldien, Junaid; Panji, Sumir; Picone, Barbara; Van Heusden, Peter (Macmillan Publishers, 2013)
      The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of ...
    • A glance at quality score: implication for de novo transcriptome reconstruction of Illumina reads 

      Mbandi, Stanley K.; Hesse, Uljana; Rees, Jasper G.; Christoffels, Alan (Frontiers, 2014)
      Downstream analyses of short-reads from next-generation sequencing platforms are often preceded by a pre-processing step that removes uncalled and wrongly called bases. Standard approaches rely on their associated base ...
    • Inferring bona fide transfrags in RNA-Seq derived-transcriptome assemblies of non-model organisms 

      Mbandi, Stanley K.; Hesse, Uljana; Van Heusden, Peter; Christoffels, Alan (BioMed Central, 2015)
      Background: De novo transcriptome assembly of short transcribed fragments (transfrags) produced from sequencing-by-synthesis technologies often results in redundant datasets with differing levels of unassembled, partially ...
    • Taste and odorant receptors of the coelecanth- a gene repertoire in transition 

      Picone, Barbara; Hesse, Uljana; Panji, Sumir; Van Heusden, Peter; Jonas, Mario; Christoffels, Alan (Wiley, 2014)
      G-protein coupled chemosensory receptors (GPCR-CRs) aid in the perception of odors and tastes in vertebrates. So far, six GPCR-CR families have been identified that are conserved in most vertebrate species. Phylogenetic ...
    • Transcriptomics of the Rooibos (Aspalathus linearis) Species Complex 

      Stander, Emily Amor; Williams, Wesley; Mgwatu, Yamkela; Hesse, Uljana; van Heusden, Peter (MDPI, 2020)
      Rooibos (Aspalathus linearis), widely known as a herbal tea, is endemic to the Cape Floristic Region of South Africa (SA). It produces a wide range of phenolic compounds that have been associated with diverse health-promoting ...
    • Virome assembly and annotation: A surprise in the Namib Desert 

      Hesse, Uljana; Van Heusden, Peter; Kirby, Bronwyn; Olonade, Israel; van Zyl, Leonardo Joaquim; Trindade, Marla (Frontiers Research Foundation, 2017)
      Sequencing, assembly, and annotation of environmental virome samples is challenging. Methodological biases and differences in species abundance result in fragmentary read coverage; sequence reconstruction is further ...