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Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort

dc.contributor.authorLeisegang, Kristian
dc.contributor.authorMenkveld, Roelof
dc.contributor.authorBouic, Patrick J.D.
dc.contributor.authorHenkel, Ralf
dc.date.accessioned2015-12-21T13:27:42Z
dc.date.available2015-12-21T13:27:42Z
dc.date.issued2014
dc.identifier.citationLeisegang, K. et al. (2014). Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort. Reproductive Biology and Endocrinology, 12(1):34en_US
dc.identifier.issn1477-7827
dc.identifier.urihttp://hdl.handle.net/10566/2032
dc.description.abstractObesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes axis, contributing to the regulation of male reproductive potential and overall wellbeing. These hormones are also present in semen influencing sperm functions. Although abdominal obesity is closely associated with insulin resistance (hyperinsulinaemia), hyperleptinaemia and glucose dysfunction, changes in seminal plasma concentrations of insulin, leptin and glucose in obese males has not previously been investigated.en_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.source.urihttp://dx.doi.org/10.1186/1477-7827-12-34
dc.subjectObesityen_US
dc.subjectReproductionen_US
dc.subjectReproductive dysfunctionen_US
dc.subjectInfertilityen_US
dc.titleObesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohorten_US
dc.typeArticleen_US
dc.privacy.showsubmitterfalse
dc.status.ispeerreviewedtrue
dc.description.accreditationWeb of Scienceen_US


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