| dc.description.abstract | Ten flavonoid-related structures viz. heliteretifolin (1), isoxanthohumol (2),
2',4',6'-trihydroxy-3'-prenylchalcone (3), isoglabranin (4), glabranin (5), 7-methoxyisoglabranin
(6), quercetin (7), 4'-methoxyquercetin (8), 4'-methoxykaempferol (9) and
mosloflavone (10) were isolated from a H. teretifolium methanolic extract and identified.
One of them (compound 1) is reported for the first time from a natural source, while
compounds 6, 8–10 were isolated for the first time from the genus Helichrysum. The total
extract of H. teretifolium showed potent antioxidant activity. When tested for total antioxidant
capacity compound 3 possesses moderate biological activity compared to 2, which displayed
some of the highest TEAC values (4529.01 ± 2.44; 4170.66 ± 6.72) µM TE/g, respectively.
Compounds 7 and 8 demonstrated the highest inhibitory activities on Fe2+-induced lipid
peroxidation (IC50 = 2.931; 6.449 µg/mL); tyrosinase (8.092; 27.573) and elastase (43.342;
86.548). Additionally, the total antioxidant capacities measured as FRAP (4816.31 ± 7.42;
3584.17 ± 0.54) µM AAE/g, and ORAC for hydroxyl radical (7.265 ± 0.71; 6.779 ± 3.40)
× 106
and peroxyl radical (17.836 ± 2.90; 12.545 ± 5.07) × 103
µM TE/g were also
observed for compounds 7 and 8, respectively. In conclusion, H. teretifolium total extract represents a rich source of bioactive constituents with potent antioxidant and moderate
anti-tyrosinase and anti-elastase activities that can help to avert accumulation of free
radicals in the body, and could therefore be good candidates for the prevention and/or
treatment of skin-related conditions, such as aging. This is the first scientific report on the
chemical and biological profile of H. teretifolium. | en_US |
