Browsing School of Pharmacy by Title
Now showing items 33-52 of 151
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Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
(UWC, 2019)Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based ... -
Comparative study on the topical and transdermal delivery of diclofenac incorporated in nano-emulsions, nano-emulgels, and a colloidal suspension
(Springer, 2022)Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The ... -
Computational applications in secondary metabolite discovery (caismd): An online workshop
(BMC, 2021)We report the major conclusions of the online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and industry ... -
Continuous professional development for public sector pharmacists in South Africa: A case study of mapping competencies in a pharmacists’ preceptor programme
(MPDI, 2020)Lifelong learning among healthcare practitioners is crucial to keep abreast of advances in therapeutic and service delivery approaches. In South Africa, continuous professional development (CPD) was mandated (2019) for ... -
The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea
(BioMed Central, 2013)Background: Tulbaghia violacea Harv. (Alliaceae) is used to treat various ailments, including hypertension (HTN) in South Africa. This study aims to evaluate the contributions of muscarinic receptors and changes in ... -
Crataegus monogyna and centella asiatica extracts as inhibitors of cathepsin s
(Horizon Research Publishing, 2022)Cathepsin cysteine proteases such as cathepsin S are responsible for the unfavorable and irreversible dysregulation of extracellular matrix (ECM) proteolysis found in cardiomyopathy, heart valve diseases and atherosclerosis. ... -
Critical appraisal of clinical guidelines for prevention and management of doxorubicin-induced cardiotoxicity
(Journal of Oncology Pharmacy Practice, 2022)Objective: Doxorubicin is a valuable chemotherapeutic drug; however, it is associated with a high risk of cardiotoxicity. Several institutions and organizations have developed guidelines for risk factor assessment, monitoring, ... -
Crystal engineering and thin-film deposition strategies towards improving the performance of kesterite photovoltaic cell
(Elsevier, 2021)With high absorption coefficient (104 cm 1), optimal bandgap (~1.5 eV), low toxicity and the abundance of its constituent elements, kesterite (Cu2ZnSnS4 or CZTS) displays the properties of an ideal photovoltaic material. ... -
Curdlan–chitosan electrospun fibers as potential scaffolds for bone regeneration
(MPDI, 2021)Polysaccharides have received a lot of attention in biomedical research for their high potential as scaffolds owing to their unique biological properties. Fibrillar scaffolds made of chitosan demonstrated high promise in ... -
Describing medicine therapy management of type 2 diabetes mellitus at primary health care facilities in Cape Town
(AOSIS, 2019)Rational medicine use aims to optimise chronic disease management and prevent episodes of hospitalisation that economically burden the health care system. Diabetes mellitus is one of the most prevalent chronic diseases ... -
The design and evaluation of ciprofloxacin-loaded nanoformulations using Ipomoea batatas starch nanoparticles
(SpringerOpen, 2023)Starch nanoparticle derivatives are gaining popularity as drug delivery vehicles because of their biocompatibility, better mechanical characteristics, heat stability properties, impediment qualities, permeability ... -
Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents
(Taylor & Francis Open Access, 2021)Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of ... -
Determination of kanamycin plasma levels using LC-MS and its pharmacokinetics in patients with multidrug-resistant tuberculosis with and without HIV-infection
(OMICS, 2015)The objectives of the study were: (1) to determine kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC-MS), (2) to investigate kanamycin pharmacokinetics (PK) in patients with ... -
Development and implementation of an integrated framework for undergraduate pharmacy training in maternal and child health at a South African university
(MPDI, 2021)The South African Pharmacy Council (SAPC) regulates undergraduate pharmacy education and pharmacy practice. The SAPC Good Pharmacy Practice manual describes the role of pharmacists in maternal and child health (MCH) in ... -
Development of a method to determine the cost of breast cancer treatment with chemotherapy at Groote Schuur Hospital, Cape Town, South Africa
(SAMA, 2020)There has been no comprehensive study determining the financial burden of breast cancer in the South African (SA) public sector. Objectives. To develop a method to determine the cost of breast cancer treatment with ... -
Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide
(Academic Journals, 2011)A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated direct inhibition (68%) of ... -
Discovery of 9-phenylacridinediones as highly selective butyrylcholinesterase inhibitors through structure-based virtual screening
(Elsevier, 2020)Butyrylcholinesterase (BuChE) is considered a promising drug target as it plays an important role in the pro-gression of late stage Alzheimer’s disease (AD). Two compound libraries were selected and 64 124 aminecontaining ... -
Do HIV infection and antiretroviral therapy influence multidrug-resistant tuberculosis treatment outcomes?
(Academic Journals, 2015)The aim of this study was to find out whether human immunodeficiency virus (HIV)-infection and antiretroviral drugs influence multidrug-resistant (MDR)-tuberculosis (TB) treatment outcomes. The study compares MDR-TB treatment ... -
Documentation of antipsychotic-related adverse drug reactions: An educational intervention
(AOSIS, 2019)Antipsychotic agents are associated with harmful adverse reactions which impact negatively on patient adherence and clinical management. Accurate and complete documentation of signs and symptoms in the clinical notes is ... -
The domestication of the African union model law on medical products regulation: perceived benefits, enabling factors, and challenges
(Frontiers Media, 2023)Introduction: In 2016, the African Union (AU) Model Law on Medical Products Regulation was endorsed by AU Heads of State and Government. The aims of the legislation include harmonisation of regulatory systems, increasing ...