Browsing School of Pharmacy by Title
Now showing items 6-25 of 37
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Cardiovascular effects of the alkaloid hippadine on the isolated perfused rat heart
(Open Access Science Research Publisher, 2012)Crinum macowanii has been used extensively in traditional medicines for treatment of various illnesses such as oedema and ‘heart disease’. Previous studies of the crude bulb extracts on Langendorff perfused isolated rat ... -
Characterization and Cradiovascular Effects of (13S)-9α,13α-epoxylabda-6β(19),15(14)diol dilactone, a Diterpenoid Isolated from Leonotis leonurus
(South African Chemical Institute, 2008)A new diterpenoid, (13S)-9 ,13 -epoxylabda-6 (19),15(14)diol dilactone (1), was isolated from Leonotis leonurus and the structure determined via NMR analysis. The compound causes significant changes in blood pressure of ... -
Clostridium difficile infection perceptions and practices: a multicenter qualitative study in South Africa
(BMC, 2018)BACKGROUND: Clostridium difficile infection (CDI) is understudied in limited resource settings. In addition, provider awareness of CDI as a prevalent threat is unknown. An assessment of current facilitators and barriers ... -
The contributions of muscarinic receptors and changes in plasma aldosterone levels to the anti-hypertensive effect of Tulbaghia violacea
(BioMed Central, 2013)Background: Tulbaghia violacea Harv. (Alliaceae) is used to treat various ailments, including hypertension (HTN) in South Africa. This study aims to evaluate the contributions of muscarinic receptors and changes in ... -
Determination of kanamycin plasma levels using LC-MS and its pharmacokinetics in patients with multidrug-resistant tuberculosis with and without HIV-infection
(OMICS, 2015)The objectives of the study were: (1) to determine kanamycin plasma concentrations using liquid chromatography coupled with mass spectrometry (LC-MS), (2) to investigate kanamycin pharmacokinetics (PK) in patients with ... -
Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide
(Academic Journals, 2011)A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated direct inhibition (68%) of ... -
Do HIV infection and antiretroviral therapy influence multidrug-resistant tuberculosis treatment outcomes?
(Academic Journals, 2015)The aim of this study was to find out whether human immunodeficiency virus (HIV)-infection and antiretroviral drugs influence multidrug-resistant (MDR)-tuberculosis (TB) treatment outcomes. The study compares MDR-TB treatment ... -
"Eat dry beans, split peas, lentils and soya regularly": a food-based dietary guideline
(Medpharm, 2013)The objective of this paper is to review recent scientific evidence to support the food-based dietary guideline (FBDG): “Eat dry beans, split peas, lentils and soya regularly”. In this review, legumes are synonymous with ... -
Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats
(BioMed Central Ltd, 2013)Background: Asystasia gangentica (A. gangetica) belongs to the family Acanthaceae. It is used to treat hypertension, rheumatism, asthma, diabetes mellitus, and as an anthelmintic in South Africa, India, Cameroun, Nigeria, ... -
Effects of Leonotis leonurus aqueous extract on the isolated perfused rat heart
(Open Access Science Research Publisher, 2012)The use the aqueous decoction of Leonotis leonurus (L. leonurus) (Ll) R. Br. (Lamiaceae) in the treatment of hypertension (HPT) in traditional medicine is well documented. The effect of the aqueous extract of LI on the ... -
Epidemiology and outcomes of Clostridium difficile infection among hospitalised patients: results of a multicentre retrospective study in South Africa
(BMJ Publishing Group, 2018)INTRODUCTION Limited data exist on Clostridium difficile infection (CDI) in low-resource settings and settings with high prevalence of HIV. We aimed to determine baseline CDI patient characteristics and management and ... -
Evaluation of the antidiarrhoeal and antidiabetic activities of the leaf aqueous extract of Syzygium cordatum hoscht. ex C.Krauss (Mytraceae) in rodents
(Asian Network for Scientific Information, 2013)Syzygium cordatum Hoscht. ex C.Krauss is widely used by traditional medicine practitioners to treat many ailments including diarrhoea and diabetes. Despite the folklore use, little evidence can be found in literature to ... -
FTIR, dissolution and anti-viral activity of nevirapine co-crystals
(OMICS International, 2017)The study uses Fourier Transform Infrared (FTIR) spectroscopy to identify five Nevirapine (NV) co-crystals, determines the dissolution profile of the co-crystals and the antiviral activity comparative to pure NV. Hot ... -
The hidden curriculum of work-based learning for pharmacy students in public sector pharmacies in South Africa
(International Pharmaceutical Federation, 2017)BACKGROUND: The work-based learning environment encompasses a dynamic space where the implementation of theoretical knowledge and skills may prove to be at odds with routine service delivery practices, known as the ... -
“I just kept quiet”: Exploring equity in a service-learning programme
(International Association for Research on Service-Learning and Community Engagement (IARSLCE), 2016)Social justice underpins the sustainable development goal of health for all. In developing countries, social injustices are particularly severe and widespread, demanding critical and immediate attention. This article describes ... -
Inorganic ions in leonotis leonurus extract do not explain changes in isolated Wistar rat heart function
(Open Access Science Research Publisher, 2011)Leonotis leonurus (L. leonurus) R. Br (Lamiaceae) is used by healers in South Africa. The present study was conducted to determine if the L. leonurus effect on isolated rat heart is due to ionic changes in the perfusion fluid. -
Involvement of gamma aminobutyric acid in the anticonvulsant effect of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice
(Asian Network for Scientific Information, 2013)The possible involvement of gamma aminobutyric acid (GABA), in the anticonvulsant effect of Ruta graveolens L. was investigated by studying the effect of the leaf methanol extract against seizures elicited by either ... -
Iterative prophylactic treatment by hematin in two cases of recurrent disabling acute intern1ittent porphyria (AIP)
(Elsevier, 1989)Summary: Hematin is known as a useful drug in the treatment of acute intermittent porphyria (Al P) attacks. We have used it with success as an iterative prophylactic treatment in two cases of AIP with recurrent disabling ... -
Microwave-assisted methods for the synthesis of pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines
(Elsevier, 2013)Efficient methodologies for the preparation of pentacyclo[5..4.0.02,6.03,10.05,9]undecane (PCU) amine derivatives are described via microwave-assisted synthesis. The obtained results revealed that microwave-assisted synthetic ... -
Multi-targeted directed ligands for Alzheimer’s disease: design of novel lead coumarin conjugates
(Taylor & Francis, 2018)Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by central nervous system insults with progressive cognitive (memory, attention) and non-cognitive (anxiety, depression) impairments. Pathophysiological ...
