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dc.contributor.authorRoberts, Tina
dc.contributor.authorStephen, Lawrence X.G.S.
dc.contributor.authorBeighton, Peter
dc.date.accessioned2018-01-08T11:55:29Z
dc.date.available2018-01-08T11:55:29Z
dc.date.issued2013
dc.identifier.citationRoberts, T. et al. (2013). Cleidocranial dysplasia: a review of the dental, historical, and practical implications with an overview of the South African experience. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 115(1): 46 – 55en_US
dc.identifier.issn2212-4403
dc.identifier.urihttp://dx.doi.org/10.1016/j.oooo.2012.07.435
dc.identifier.urihttp://hdl.handle.net/10566/3362
dc.description.abstractCleidocranial dysplasia (CCD) is an uncommon but well-known genetic skeletal condition. Several hundred affected persons are members of a large extended family in the Cape Town Mixed Ancestry community of South Africa. The clinical manifestations are often innocuous, but hyperdontia and other developmental abnormalities of the teeth are a major feature and may require special dental management. Over the past 40 years, the authors have encountered more than 100 affected persons in Cape Town. Emphasis has been on dental management, but medical, genetic, and social problems have also been addressed. In this article, we have reviewed the manifestations of the disorder in the light of our own experience, and performed a literature search with emphasis on the various approaches to dental management and treatment options in CCD. Advances in the understanding of the biomolecular pathogenesis of CCD are outlined and the international and local history of the disorder is documented.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsThis is the author-version of the article published online at: http://dx.doi.org/10.1016/j.oooo.2012.07.435
dc.subjectCleidocranial dysplasia (CCD)en_US
dc.subjectGenetic skeletal conditionen_US
dc.subjectHyperdontiaen_US
dc.subjectDisorderen_US
dc.subjectBiomolecular pathogenesisen_US
dc.titleCleidocranial dysplasia: a review of the dental, historical, and practical implications with an overview of the South African experienceen_US
dc.typeArticleen_US
dc.privacy.showsubmitterFALSE
dc.status.ispeerreviewedTRUE
dc.description.accreditationWeb of Science


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