Browsing Medical Bioscience by Title
Now showing items 82-101 of 277
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The effects of endocrine disrupting chemicals on biomarkers of inflammation produced by lipopolysaccharide stimulated raw264.7 macrophages
(MDPI, 2019)Endocrine disrupting chemicals (EDCs) are common pollutants in the environment and can induce disruption of the endocrine and immune systems. The present study evaluated the effects of selected common environmental EDCs ... -
Effects of GnRH vaccination in wild and captive African Elephant bulls (Loxodonta africana) on reproductive organs and semen quality
(Public Library of Science, 2017)OBJECTIVES: Although the African elephant (Loxodonta africana) is classified as endangered by the International Union for Conservation of Nature (IUCN), in some isolated habitats in southern Africa, contraception is of ... -
Effects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW264.7 and human whole blood cell cultures
(MDPI, 2018)Graphene oxide nanoparticles (GONPs) have attracted a lot of attention due to their many applications. These applications include batteries, super capacitors, drug delivery and biosensing. However, few studies have ... -
The effects of in utero exposure to teratogens on organ size: A prospective paediatric study
(Cambridge University Press, 2021)In low-income countries, prospective data on combined effects of in utero teratogen exposure are lacking and necessitates new research. The aim of the present study was to explore the effect of in utero teratogen exposure ... -
The effects of silver nanoparticles on RAW 264.7. Macrophages and human whole blood cell cultures
(University of the Western Cape, 2019)Silver nanoparticles (AgNPs) are commonly found in consumer products due to their antimicrobial properties. This study evaluated the effects of AgNPs on the murine macrophage cell line RAW 264.7 and human whole blood cell ... -
Effects of temperature and storage time on the motility, viability, DNA integrity and apoptosis of processed human spermatozoa
(Wiley, 2019)The aim of this study was to evaluate motility, viability, DNA integrity and apoptosis of spermatozoa when washed semen samples were kept for up to 12 days at 4–6°C and 25°C. In this experimental study, 26 normozoospermic ... -
Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia
(John Wiley and Sons Inc, 2021)In this study, we investigated the prevalence of sexual dysfunction among males with advanced chronic kidney disease and the effect of treating hyperprolactinemia among these patients. In this prospective study, patients ... -
Environmental contaminants and male infertility: Effects and mechanisms
(Blackwell Publishing Ltd, 2021)The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. ... -
Enzymatic detoxification of the fumonisin mycotoxins during dry milling of maize
(Elsevier, 2021)Fumonisin esterase FumD (EC 3.1.1.87), FUMzyme® (BIOMIN, Austria), effectively detoxifies fumonisin B mycotoxins (FB) by hydrolysis and removal of the tricarballylic acid groups. The current study evaluated FumD detoxification ... -
Epididymal contribution to male infertility: An overlooked problem
(Blackwell Publishing Ltd, 2021)The diagnosis and treatment of male infertility, excluding assisted conception, are limited because of, but not limited to, poor understanding of sperm post-testicular development and storage. Many may think that sperm ... -
Ethnopharmacology, therapeutic properties and nutritional potentials of Carpobrotus edulis: A comprehensive review
(MPDI, 2020)Carpobrotus edulis, formerly known as Mesembryanthemum edule L, belongs to the Aizoaceae family of plants. It is a facultative halophytic invasive medicinal and edible succulent plant that is native to South Africa and ... -
Etiologies of sperm DNA damage and its impact on male infertility
(Blackwell Publishing Ltd, 2021)Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is considered the cornerstone of laboratory evaluation of male infertility, but it has its own drawbacks and fails to predict the ... -
Evaluation of reference values of standard semen parameters in fertile Egyptian men
(Wiley, 2018)The reference values of human semen, published in the WHO’s latest edition in 2010, were lower than those previously reported. The objective of this study was to evaluate reference values of standard semen parameters in ... -
Evaluation of seminal oxidation–reduction potential in male infertility
(Blackwell Publishing Ltd, 2021)The role of oxidative stress in male infertility has been broadly recognised, and the search for a new marker to determine the redox environment in semen has gained considerable interest. Oxidation–reduction potential (ORP) ... -
Evaluation of synergistic anticandidal activity of galenia africana extract and fluconazole against candida albicans and candida glabrata
(Elsevier, 2022-03)Candida infections have increased in recent years and are causing a serious public health concern. In addition, Candida species are becoming resistant to numerous antifungal drugs. It is for this reason that alternative ... -
Examination of maternal gingival crevicular fluid for the presence of selected periodontopathogens implicated in the pre-term delivery of low birthweight infants
(Landes Bioscience, 2010)Background: Reports show that more than 20 million infants world-wide are born prematurely with 95% of all pre-term births occurring in developing countries. Oral colonization of Gram-negative anaerobes has been implicated ... -
The excessive use of antioxidant therapy: A possible cause of male infertility?
(Wiley, 2018)Reactive oxygen species and oxidative stress are closely associated with various pathologies such as neurodegenerative diseases, ageing and male infertility. Hence, antioxidants such as vitamin C, vitamin E, N‐acetyl ... -
Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesis
(Frontiers Media, 2022)The blood-brain barrier (BBB) is a robust interface between the blood and the central nervous system. Barrier type endothelium is able to limit paracellular (PC) movement, relegating molecular flux to the transendothel ... -
An exploratory study of contractile force production in muscle fibers from patients with inflammatory myopathies
(Wiley-Blackwell, 2020)Introduction: The mechanism by which weakness develops in idiopathic inflammatory myopathies (IIMs) is still unclear. In this study we investigated the maximum force of single muscle fibers from patients with IIMs. Methods: ... -
Expression, purification and preliminary crystallographic analysis of recombinant human DEAD-box polypeptide 5
(International Union of Crystallography, 2010)The DEAD-box RNA helicase DDX5 is involved in many aspects of RNA processing and has been implicated in a number of cellular processes involving alteration of RNA secondary structure. The N-terminal region of DDX5, ...
