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The African Coelecanth genome provides insights into tetrapod evolution
(Macmillan Publishers, 2013)
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of ...
Self-similarity of human protein interaction networks: a novel strategy of distinguishing proteins
(2015)
The successful determination of reliable protein interaction networks (PINs) in several species in the
post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of
such networks. ...
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
(Nature Publishing Group, 2017)
The Southern African Human Genome Programme is a national initiative that aspires to
unlock the unique genetic character of southern African populations for a better understanding
of human genetic diversity. In this pilot ...
A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer
(BioMed Central, 2018)
BACKGROUND: Gene expression can be employed for the discovery of prognostic gene or multigene signatures
cancer. In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway ...
Exome sequencing identifies novel dysferlin mutation in a family with paucisymptomatic heterozygous carriers
(BioMed Central, 2018)
BACKGROUND: We investigated a South African family of admixed ancestry in which the first generation (G1) developed
insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ...
Defining the molecular signatures of Achilles tendinopathy and anterior cruciate ligament ruptures: A whole-exome sequencing approach
(Public Library of Science, 2018)
Musculoskeletal soft tissue injuries are complex phenotypes with genetics being one of
many proposed risk factors. Case-control association studies using the candidate gene
approach have predominately been used to identify ...
Defining the molecular signatures of Achilles tendinopathy and anterior cruciate ligament ruptures: A whole-exome sequencing approach
(Public Library of Science, 2018)
Musculoskeletal soft tissue injuries are complex phenotypes with genetics being one of
many proposed risk factors. Case-control association studies using the candidate gene
approach have predominately been used to identify ...
Exome sequencing identifies novel dysferlin mutation in a family with pauci-symptomatic heterozygous carriers
(Springer Nature, 2018)
Background: We investigated a South African family of admixed ancestry in which the first generation (G1) developed
insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ...
Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles
(Impact Journals, 2020)
Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic ...