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Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics
(Springer Nature, 2018)
Background: The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African
countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
Opportunities in Africa for training in genome science
(Academic Journals, 2004)
Genome science is a new type of biology that unites genetics, molecular biology, computational
biology and bioinformatics. The availability of the human genome sequence, as well as the genome
sequences of several other ...
Ten simple rules for developing bioinformatics capacity at an academic institution
(Public Library of Science, 2021)
Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and
deploy computational techniques to store, organize, and aid in the analysis and interpretation
of large-scale data obtained ...
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
(Oxford University Press, 2018)
Triplet amino acids have successfully been included in feature selection to predict
human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is
curtailed due to experimental data not being ...
The combat-tb workbench: Making powerful Mycobacterium tuberculosis bioinformatics accessible
(American Society for Microbiology, 2022)
Whole-genome sequencing (WGS) is a powerful method for detecting drug resistance, genetic diversity, and transmission dynamics of Mycobacterium tuberculosis. Implementation of WGS in public health microbiology laboratories ...
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
(Nature Research, 2016)
Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired
performance during activity. Candidate gene association studies have identified genetic factors
that contribute to ...
Investigation of distinct gene expression profile patterns that can improve the classification of intermediate-risk prognosis in AML patients
(Frontiers Media, 2023)
Acute myeloid leukemia (AML) is a heterogeneous type of blood cancer that generally affects the elderly. AML patients are categorized with favorable-, intermediate-, and adverse-risks based on an individual’s genomic ...
SysBiolPGWAS: Simplifying post-GWAS analysis through the use of computational technologies and integration of diverse omics datasets
(Oxford University Press, 2023)
Post-genome-wide association studies (pGWAS) analysis is designed to decipher the functional consequences of significant single-nucleotide polymorphisms (SNPs) in the era of GWAS. This can be translated into
research ...