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Virome assembly and annotation: A surprise in the Namib Desert
(Frontiers Research Foundation, 2017)
Sequencing, assembly, and annotation of environmental virome samples is challenging. Methodological biases and differences in species abundance result in fragmentary read coverage; sequence reconstruction is further ...
Cross-species multiple environmental stress responses: An integrated approach to identify candidate genes for multiple stress tolerance in sorghum (Sorghum bicolor (L.) Moench) and related model species
(Public Library of Science, 2018)
BACKGROUND
Crop response to the changing climate and unpredictable effects of global warming with
adverse conditions such as drought stress has brought concerns about food security to the
fore; crop yield loss is a major ...
Carbonic anhydrase II based biosensing of carbon dioxide at high temperature: an analytical and MD simulation study
(OMICS International, 2018)
Concentration of carbon dioxide (CO2) in the atmosphere has increased significantly due to anthropogenic
activities and attributed as a major factor to global warming. Its detection by biosensing methods will provide ...
Selecting an appropriate method for expressing S locus F-box-S2 recombinant protein
(Elsevier, 2017)
A single locus (S locus) including at least two linked genes (female and male determinants) genetically controls
the gametophytic self-incompatibility (GSI) in apple, which has evolved to avoid self-fertilization. There ...
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
(Nature Publishing Group, 2017)
The Southern African Human Genome Programme is a national initiative that aspires to
unlock the unique genetic character of southern African populations for a better understanding
of human genetic diversity. In this pilot ...
A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer
(BioMed Central, 2018)
BACKGROUND: Gene expression can be employed for the discovery of prognostic gene or multigene signatures
cancer. In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway ...
Hackathons as a means of accelerating scientific discoveries and knowledge transfer
(Cold Spring Harbor Laboratory Press, 2018)
Scientific research plays a key role in the advancement of human knowledge and pursuit of solutions to important societal
challenges. Typically, research occurs within specific institutions where data are generated and ...
A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without
(BioMed Central, 2017)
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a complex, multi-systemic, autoimmune disease for which the
underlying aetiological mechanisms are poorly understood. The genetic and molecular processes underlying ...
Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and available of integrase inhibitors in Cape Town, South Africa
(Nature Publishing Group, 2018)
HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to
characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations
(RAMs) against ...
Castleman’s disease in the HIV-endemic setting
(Dovepress, 2018)
Castleman’s disease (CD), first described by Benjamin Castleman in 1954, is a
giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell
lymphoproliferative disorder with an incompletely ...