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Now showing items 51-60 of 79
DDPC: Dragon database of genes associated with prostate cancer
(Oxford Journals, 2011)
Prostate cancer (PC) is one of the most commonly diagnosed cancers in men. PC is relatively difficult to diagnose due to a lack of clear early symptoms. Extensive research of PC has led to the availability of a large amount ...
Careful governance of African biobanks
(Elsevier, 2020)
The Sydney Statement is one of
the first framing documents on the
principles for guiding global health
security. Framing matters because
the funding pool for development
assistance for health is finite and has
plateaued ...
Inferring bona fide transfrags in RNA-Seq derived-transcriptome assemblies of non-model organisms
(BioMed Central, 2015)
Background: De novo transcriptome assembly of short transcribed fragments (transfrags) produced from sequencing-by-synthesis technologies often results in redundant datasets with differing levels of unassembled, partially ...
Self-similarity of human protein interaction networks: a novel strategy of distinguishing proteins
(2015)
The successful determination of reliable protein interaction networks (PINs) in several species in the
post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of
such networks. ...
Molecular evolution of key receptor genes in primates and non-human primates
(Science Publishing Group, 2014)
African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in ...
A glance at quality score: implication for de novo transcriptome reconstruction of Illumina reads
(Frontiers, 2014)
Downstream analyses of short-reads from next-generation sequencing platforms are often preceded by a pre-processing step that removes uncalled and wrongly called bases. Standard approaches rely on their associated base ...
Genome-wide SNP identification by high-throughput sequencing and selective mapping allows sequence assembly positioning using a framework genetic linkage map
(BioMed Central, 2010)
Determining the position and order of contigs and scaffolds from a genome assembly within an organism’s genome remains a technical challenge in a majority of sequencing projects. In order to exploit contemporary technologies ...
Gonad differentiation in zebrafish is regulated by the canonical Wnt signalling pathway
(Society for the Study of Reproduction, 2014)
Zebrafish males undergo a ‘‘juvenile ovary-to-testis’’ gonadal transformation process. Several genes, including nuclear receptor subfamily 5, group A (nr5a) and anti-Mu¨ llerian hormone (amh), and pathways such as Tp53-mediated ...
DAMPD: a manually curated antimicrobial peptide database
(Oxford University Press, 2012)
The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates ...
Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa
(Frontiers Media S.A., 2020)
The South African national combination antiretroviral therapy (cART) roll-out program started in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 drug resistance can hamper the ...