Research Articles (SANBI): Recent submissions
Now showing items 1-20 of 76
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Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C integrase-dolutegravir binding
(Public Library of Science, 2020)Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a ... -
Genome sequencing of a severe acute respiratory syndrome Coronavirus 2 isolate obtained from a South African patient with Coronavirus disease 2019
(American Society for Microbiology, 2020)As a contribution to the global efforts to track and trace the ongoing coronavirus pandemic, here we present the sequence, phylogenetic analysis, and modeling of nonsynonymous mutations for a severe acute respiratory ... -
Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in South Africa
(Frontiers Media S.A., 2020)The South African national combination antiretroviral therapy (cART) roll-out program started in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 drug resistance can hamper the ... -
Intact HIV proviruses persist in children seven to nine years after initiation of antiretroviral therapy in the first year of life
(American Society for Microbiology, 2020)In adults starting antiretroviral therapy (ART) during acute infection, 2% of proviruses that persist on ART are genetically intact by sequence analysis. In contrast, a recent report in children treated early failed to ... -
Functional and structural analysis of predicted proteins obtained from homo sapiens' minisatellite 33.15-tagged transcript pAKT-45 variants
(Hindawi, 2020)The spermatozoa are transcriptionally dormant entities which have been recognized to be an archive of mRNA, coding for a variety of functionally crucial cellular proteins. This significant repository of mRNA is predicted ... -
HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy
(SAMA, 2020): The integrase (IN) strand-transfer inhibitor (InSTI) dolutegravir (DTG) is now recommended by the World Health Organization as part of salvage and/or first-line combination antiretroviral therapy (cART).[1] DTG has a ... -
Careful governance of African biobanks
(Elsevier, 2020)The Sydney Statement is one of the first framing documents on the principles for guiding global health security. Framing matters because the funding pool for development assistance for health is finite and has plateaued ... -
Structural comparison of diverse HIV-1 subtypes using molecular modelling and docking analyses of integrase inhibitors
(MPDI, 2020)The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by several drugs; ... -
Modelling the impact of maternal HIV on uninfected children: correcting current estimates
(Taylor & Francis, 2020)A mathematical model, populated primarily with data from South Africa, was developed to model the numbers of children affected by maternal HIV, and the number who will experience long-term negative developmental consequences. ... -
Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles
(Impact Journals, 2020)Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic ... -
Multistage antiplasmodial activity of hydroxyethylamine compounds,in vitroandin vivoevaluations
(Royal Society of Chemistry, 2020)Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of Plasmodium species. New therapeutics acting against the pathogenic asexual and sexual stages, ... -
Diverse genomoviruses representing twenty-nine species identified associated with plants
(Springer Nature, 2020)Genomoviruses (family Genomoviridae) are circular single-stranded DNA viruses that have been mainly identifed through metagenomics studies in a wide variety of samples from various environments. Here, we describe 98 genomes ... -
Symptom evolution following the emergence of maize streak virus
(eLife Sciences Publications, 2020)For pathogens infecting single host species evolutionary trade-offs have previously been demonstrated between pathogen-induced mortality rates and transmission rates. It remains unclear, however, how such trade-offs ... -
Cellular and molecular targets of waterbuck repellent blend odors in antennae of glossina fuscipes fuscipes newstead, 1910
(Frontiers Media S.A., 2020)Insects that transmit many of the world’s deadliest animal diseases, for instance trypanosomosis, find their suitable hosts and avoid non-preferred hosts mostly through olfactory cues. The waterbuck repellent blend (WRB) ... -
Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6
(MDPI, 2020)Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus, it is considered as an attractive drug target in anticancer therapeutics. This study presents an evaluation of dietary phytochemicals, ... -
COMBAT-TB-NeoDB: Fostering tuberculosis research through integrative analysis using graph database technologies
(Oxford University Press, 2020)Tuberculosis (TB) is a significant global health threat, with onethird of the population infected with its causative agent Mycobacterium tuberculosis (M.tb). Globally, researchers have been responding with a plethora of ... -
Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics
(Dove Medical Press, 2020)Several studies have explored the design of antimicrobial peptides (AMPs) for the development of therapeutic and diagnostic molecules for the treatment and identification of pathogenic diseases as well as cancer. Human ... -
Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus, it is considered as an attractive drug target in anticancer therapeutics. This study presents an evaluation of dietary phytochemicals, ... -
Conceptualising COVID-19’s impacts on household food security
(Springer, 2020)COVID-19 undermines food security both directly, by disrupting food systems, and indirectly, through the impacts of lockdowns on household incomes and physical access to food. COVID-19 and responses to the pandemic could ... -
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study
(International Journal of Biological Macromolecules, 2019)The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in Mycobacteriumtuberculosis drive a need for the formulation of novel therapeutic agents. The diarylquinoline ...
