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Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a subset of 237 donors in the South African Bone Marrow Registry

Tshabalala, Mqondisi; Ingram, Charlotte; Schlaphoff, Terry; Borrill, Veronica; Christoffels, Alan; Pepper, Michael S. (Hindawi, 2018)

Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry ...

Odorant and gustatory receptors in the tsetse fly Glossina morsitans morsitans

Obiero, George F.; Nyanjom, Steven R. G.; Mireji, Paul O.; Christoffels, Alan; Robertson, Hugh M.; Masiga, Daniel K. (PLOS, 2014)

Tsetse flies use olfactory and gustatory responses, through odorant and gustatory receptors (ORs and GRs), to interact with their environment. Glossina morsitans morsitans genome ORs and GRs were annotated using homologs ...

Human African trypanosomiasis research gets booost: unravelling the tsetse Genome

Aksoy, Serap; Attardo, Geoffrey; Berriman, Matthew; Christoffels, Alan; Lehane, Mike; Masiga, Daniel K.; Toure', Yeya (PLOS, 2014)

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub-Saharan Africa. Trypanosoma brucei gambiense accounts for ...

International Glossina Genome Initiative 2004-2014: a driver for post-genomic era research on the African continent

Christoffels, Alan; Masiga, Daniel K.; Berriman, Matthew; Lehane, Mike; Toure', Yeya; Aksoy, Serap (PLOS, 2014)

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub- Saharan Africa and includes at least 50% of the population ...

Genome sequence of the tsetse fly (glossina morsitans): vector of African trypanosomiasis

Christoffels, Alan; Obiero, George F.; Harkins, Gordon William (American Association for the Advancement of Science, 2014)

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between ...

An integrated and comparative approach towards identification, characterization and functional annotation of candidate genes for drought tolerance in sorghum (Sorghum bicolor (L.) Moench)

Woldesemayat, Adugna Abdi; Van Heusden, Peter; Ndimba, Bongani K.; Christoffels, Alan (BioMed Central, 2017)

BACKGROUND: Drought is the most disastrous abiotic stress that severely affects agricultural productivity worldwide. Understanding the biological basis of drought-regulated traits, requires identification and an in-depth ...

Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach

Egieyeh, Samuel; Syce, James; Malan, Sarel F.; Christoffels, Alan (Public Library of Science, 2018)

In view of the vast number of natural products with potential antiplasmodial bioactivity and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from previous antiplasmodial bioassays and ...

Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study

Cloete, Ruben; Grobbelaar, Melanie; Sampson, Samantha; Christoffels, Alan (International Journal of Biological Macromolecules, 2019)

The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in Mycobacteriumtuberculosis drive a need for the formulation of novel therapeutic agents. The diarylquinoline ...

Designing novel possible kinase inhibitor derivatives as therapeutics against Mycobacterium tuberculosis: An in silico study

Shahbaaz, Mohd; Nkaule, Anati; Christoffels, Alan (Scientific Reports, 2019)

Rv2984 is one of the polyphosphate kinases present in Mycobacterium tuberculosis involved in the catalytic synthesis of inorganic polyphosphate, which plays an essential role in bacterial virulence and drug resistance. ...

Cross-species multiple environmental stress responses: An integrated approach to identify candidate genes for multiple stress tolerance in sorghum (Sorghum bicolor (L.) Moench) and related model species

Woldesemayat, Adugna Abdi; Modise, David M.; Gemeildien, Junaid; Ndimba, Bongani K.; Christoffels, Alan (Public Library of Science, 2018)

BACKGROUND Crop response to the changing climate and unpredictable effects of global warming with adverse conditions such as drought stress has brought concerns about food security to the fore; crop yield loss is a major ...