Browsing Research Articles (School of Pharmacy) by Title
Now showing items 103-122 of 151
-
Pharmacists’ approach to optimise safe medication use in paediatric patients
(MPDI, 2021)Paediatric patients are unique, yet challenging patients to care for by pharmacists. Paediatric medicine use requires special consideration. Pharmacists play an important role in educating and counselling patients, carers, ... -
Pharmacokinetics of vancomycin in critically Ill children: A systematic review
(European journal of drug metabolism and pharmacokinetics, 2021)Background and Objective Vancomycin is often used in the ICU for the treatment of Gram-positive bacterial infection. In critically ill children, there are pathophysiologic changes that afect the pharmacokinetics of vancomycin. ... -
Physicochemical stability of enriched phenolic fractions of cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones
(Georg Thieme Verlag, 2021)Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α -glucosidase in vitro. The present study investigated ex vivo ... -
Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils
(De Gruyter, 2023)Phytochemical constituents are important in the determination of plant activities. Their presence in medicinal plants gives their therapeutic values. These phytoconstituents possesses pharmacological activities that include ... -
A pilot study to test psychophonetics methodology for self-care and empathy in compassion fatique, burnout and secondary traumatic stress
(AOSIS OpenJournals, 2013)Background: Home-based care is recognised as being a stressful occupation. Practitioners working with patients experiencing high levels of trauma may be susceptible to compassion fatigue, with the sustained need to remain ... -
Polymer-based protein delivery systems for loco-regional administration
(Taylor and Francis Group, 2021)With the advent of recombinant technology, a wide variety of biocompatible therapeutic proteins can be produced with relative ease. These proteins are formulated and subsequently administered in patients to treat various ... -
A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa
(Journal of Applied Pharmaceutical Science, 2019)South Africa has the world’s largest antiretroviral (ARV) program and despite having stringent upstream medicine’s regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The ... -
Potential beneficial effects of Tulbaghia violacea William Henry Harvey (Alliaceae) on cardiovascular system - A review
(Pharmacotherapy Group, University of Benin, 2015)Tulbaghia violacea William Henry Harvey (Harv. Alliaceae) is a small bulbous herb belonging to the family Alliaceae. It is used in South Africa to treat fever, colds, asthma, paralysis, and hypertension. Meanwhile, ... -
Preceptor reflections on the Community Health clinical rotation for fourth year pharmacy students at the University of the Western Cape
(2019)This paper describes the community health clinic rotation of the Patient Care Experience programme (PaCE) offered to fourth year pharmacy students (2018) at the University of the Western Cape. Reflections from the collective ... -
Preparation and evaluation of pralidoxime-loaded plga nanoparticles as potential carriers of the drug across the blood brain barrier
(Hindawi, 2015)Pralidoxime is an organophosphate antidote with poor central nervous system distribution due to a high polarity. In the present study, pralidoxime-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared and ... -
Proprotein convertase subtilisin/kexin type 9 genetic screening using the vervet (Chlorocebus aethiops) model
(Journal of Medical Primatology, 2022)Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has come to prominence due to its reported function in the clearance of low-density li-poprotein cholesterol. The vervet monkey (Chlorocebus ... -
Provision of syndromic treatment of sexually transmitted infections by community pharmacists: a potentially underutilized HIV prevention strategy
(Lippincott, Williams & Wilkins, 2003)Background: Sexually transmitted infections (STIs) are known risk factors for HIV infection. Goal: The goal of this study was to assess the current and potential future role that community pharmacists in Western Cape, South ... -
Pulmonary effects and disposition of luteolin and Artemisia afra extracts in isolated perfused lungs
(Elsevier, 2013)ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia afra (Asteraceae) is a traditional medicinal plant frequently used in steam inhalation form to treat respiratory conditions. AIM OF THE STUDY: Quantify luteolin content in Artemisia ... -
A qualitative meta-synthesis of facilitators and barriers to tuberculosis diagnosis and treatment in Nigeria
(Springer Nature, 2021): Despite progress in tuberculosis (TB) control globally, TB continues to be a leading cause of death from infectious diseases, claiming 1.2 million lives in 2018; 214,000 of these deaths were due to drug resistant strains. ... -
Re-engineering of South Africa’s primary health care system: where is the pharmacist?
(South African Academy of Family Physicians, 2016)South Africa’s transition towards a district-based health system (DHS) aims to offer health promotion and prevention services at community level, through re-engineered primary health care (PHC) services. Along with pharmacy ... -
Reasons for missed appointments linked to a public-sector intervention targeting patients with stable chronic conditions in South Africa: results from in-depth interviews and a retrospective review of medical records
(BioMed Central, 2017)BACKGROUND Missed appointments serve as a key indicator for adherence to therapy and as such, identifying patient reasons for this inconsistency could assist in developing programmes to improve health outcomes. In this ... -
Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications
(MDPI, 2021)The risk of secondary bacterial infections resulting from dental procedures has driven the design of antimicrobial and antifouling dental materials to curb pathogenic microbial growth, biofilm formation and subsequent ... -
Regulatory registration timelines of generic medicines in South Africa: Assessment of the performance of SAHPRA between 2011 and 2022
(Springer, 2023)Various regulatory authorities are experiencing backlogs of applications which result in delayed access to medicines for patients. The objective of this study is to critically assess the registration process utilised by ... -
A retrospective analysis of applications for registration of generic medicines processed by the medicines control authority of Zimbabwe
(Springer, 2023)Many applications for registration of medicines are rejected because applicants fail to submit or resolve critical deficiencies in the quality, efficacy, and safety of the medicines. The study aimed to establish approval ... -
A retrospective descriptive investigation of adult patients receiving third-line antiretroviral therapy in the North West province, South Africa
(Makerere University, 2020)Greater access and prolonged exposure to ART may inevitably lead to more treatment failure and increase the need for third-line ART (TLART) in a resource-limited setting. Objective: To describe characteristics and resistance ...