Browsing Research Articles (School of Pharmacy) by Issue Date
Now showing items 41-60 of 151
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Small molecule efflux pump inhibitors in Mycobacterium tuberculosis: a rational drug design perspective
(Bentham Science Publishers, 2018)Drug resistance in Mycobacterium tuberculosis (M. tuberculosis) complicates management of tuberculosis. Efflux pumps contribute to low level resistance and acquisition of additional high level resistance mutations through ... -
Synthesis and biological evaluations of NO-donating oxa- and aza-pentacycloundecane derivatives as potential neuroprotective candidates
(MDPI, 2018)In order to utilize the neuroprotective properties of polycyclic cage compounds, and explore the NO-donating ability of nitrophenyl groups, an array of compounds was synthesized where the different nitrophenyl groups ... -
Allergic rhinitis: To sneeze or to wheeze. Pollen is the question, what is the answer?
(Medpharm Publications, 2018)Allergic rhinitis, also known colloquially as hay fever, is the most common among the allergic diseases. Recent literature reports that it affects up to a tenth of the world population. Atopic diseases have a particularly ... -
A "site" for sore eyes
(South African Academy of Family Physicians, 2018)It is known that not all red eyes are caused by infections. Furthermore, not all eye infections will react to antibiotic eye drops. Most cases of conjunctivitis are due to viral causes, do not require antibiotic eye drops ... -
Patient with Kaposi’s Sarcoma: Teaching students medicine management therapy
(Medpharm, 2018)Interprofessional education (IPE) is a cornerstone in advancing health professional education, with the aim of improving the overall quality of healthcare.1 The World Health Organization (WHO) states: “Interprofessional ... -
An interesting case of carbamazepine-induced Stevens–Johnson Syndrome
(Springer, 2018)A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 ... -
Medicine Runners: A community-initiated solution to chronic medicine access in underserved communities
(Medpharm, 2018)Patient access to chronic medicines is crucial in optimising disease management. With the introduction of a decentralised chronic dispensing unit, stable patients qualify to have access to their chronic medicines away ... -
Epidemiology and outcomes of Clostridium difficile infection among hospitalised patients: results of a multicentre retrospective study in South Africa
(BMJ Publishing Group, 2018)INTRODUCTION Limited data exist on Clostridium difficile infection (CDI) in low-resource settings and settings with high prevalence of HIV. We aimed to determine baseline CDI patient characteristics and management and ... -
Leopard tortoises in southern Africa have greater genetic diversity in the north than in the south (Testudinidae)
(Wiley, 2018)In contrast to mammals, little is known about the phylogeographic structuring of widely distributed African reptile species. With the present study, we contribute data for the leopard tortoise (Stigmochelys pardalis). It ... -
Nanomedicines for infectious diseases
(Springer Nature, 2019)Infectious diseases continue to pose a significant threat to global health. Over 200 infectious diseases are currently known to man. Fortunately, only a handful are responsible for significant morbidity and mortality. ... -
Preceptor reflections on the Community Health clinical rotation for fourth year pharmacy students at the University of the Western Cape
(2019)This paper describes the community health clinic rotation of the Patient Care Experience programme (PaCE) offered to fourth year pharmacy students (2018) at the University of the Western Cape. Reflections from the collective ... -
Synthesis, Crystal Structure, DFT Studies, Docking Studies, and Fluorescent Properties of 2-(Adamantan-1-yl)-2H-isoindole-1-carbonitrile
(MDPI, 2019)2-(Adamantan-1-yl)-2H-isoindole-1-carbonitrile (1) has been identified as a neurobiological fluorescent ligand that may be used to develop receptor and enzyme binding affinity assays. Compound 1 was synthesized using an ... -
Structural analysis, molecular modelling and preliminary competition bnding studies of AM-DAN as a NMDA Receptor PCP-Site Fluorescent Ligand
(MDPI, 2019)Excitotoxicity related to the dysfunction of the N-methyl-d-aspartate receptor (NMDAR) has been indicated to play an integral role in the pathophysiology of multiple disease states, including neurodegenerative disorders ... -
A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa
(Journal of Applied Pharmaceutical Science, 2019)South Africa has the world’s largest antiretroviral (ARV) program and despite having stringent upstream medicine’s regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The ... -
Comparative in vitro transportation of pentamidine across the blood-brain barrier using polycaprolactone nanoparticles and phosphatidylcholine liposomes
(UWC, 2019)Nanoparticles (NPs) have gained importance in addressing drug delivery challenges across biological barriers. Here, we reformulated pentamidine, a drug used to treat Human African Trypanosomiasis (HAT) in polymer based ... -
Steady‐state population pharmacokinetics of terizidone and itsmetabolite cycloserine in patients with drug‐resistanttuberculosis
(Wiley, 2019)Despite terizidone being part of the second‐line recommended drugs fortreatment of drug‐resistant tuberculosis (DR‐TB), information on its pharmacokineticsis scarce. The aim of this study was to describe the steady‐state ... -
Exploring practising pharmacy graduates’ views on improving the effectiveness of pharmacy education at the University of the Western Cape, South Africa
(HEALTH & MEDICAL PUBLISHING GROUP, 2019)South African health professional education institutions have a mandate to produce graduates who are able to address priority needs of the healthcare system and larger society. However, evidence of the effective use of ... -
Exploring the implications of a needs-based pharmacy education framework modelled on population health: Perspective from a developing country
(MDPI, 2019)Globally, health education reform is directing efforts to strengthen the health system through collaboration between health education and health services. However, collaborative efforts vary between developed and developing ... -
Amount of cycloserine emanating from terizidone metabolism and relationship with hepatic function in patients with drug resistant tuberculosis
(Springer, 2019)The dosing of cycloserine and terizidone is the same, as both drugs are considered equivalent or used interchangeably. Nevertheless, it is not certain from the literature that these drugs are interchangeable. Therefore, the ... -
Describing medicine therapy management of type 2 diabetes mellitus at primary health care facilities in Cape Town
(AOSIS, 2019)Rational medicine use aims to optimise chronic disease management and prevent episodes of hospitalisation that economically burden the health care system. Diabetes mellitus is one of the most prevalent chronic diseases ...