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A qualitative meta-synthesis of facilitators and barriers to tuberculosis diagnosis and treatment in Nigeria
(Springer Nature, 2021)
: Despite progress in tuberculosis (TB) control globally, TB continues to be a leading cause of death
from infectious diseases, claiming 1.2 million lives in 2018; 214,000 of these deaths were due to drug resistant
strains. ...
Evaluating pharmacy students’ knowledge and skills in reproductive, maternal, new-born and child health care at a South African university
(Springer Nature, 2021)
Maternal and child mortality is a global concern and one of South Africa’s quadruple burdens of
disease. As easily accessible frontline healthcare workers, pharmacists play an important role in the continuum of
maternal ...
Assessment of Vancomycin Pharmacokinetics and Dose Regimen Optimisation in Preterm Neonates
(Springer Nature, 2020)
The pharmacokinetics of vancomycin, a drug used for the treatment of methicillin-resistant Staphylococcus
aureus (MRSA), varies between paediatric and adult patients.
The objective of this study was to assess the ...
Computational applications in secondary metabolite discovery (caismd): An online workshop
(BMC, 2021)
We report the major conclusions of the online open-access workshop “Computational Applications in Secondary
Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and
industry ...
Antibacterial Activities of Selected Green Seaweeds from West African Coast
(EC Pharmacology and Toxicology ECronicon Open Access, 2020)
The continually increasing antibiotic resistance amongst microorganisms had steered up an increased intensity in the search
for new drugs. The marine environment had been reported to be a great source of novel compounds ...
4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as nmda receptor- And VGCC blockers with neuroprotective potential
(MPDI, 2020)
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development ...
Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents
(Arkat USA, 2020)
Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, ...
Mechanochemical synthesis and physicochemical characterization of isoniazid and pyrazinamide co-crystals with Glutaric acid
(Frontiers Media S.A., 2020)
The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of ...
Encapsulation of variabilin in stearic acid solid lipid nanoparticles enhances its anticancer activity in vitro
(MDPI, 2020)
The use of natural products as chemotherapeutic agents is well established; however, many of these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development of drug ...
Physicochemical stability of enriched phenolic fractions of cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones
(Georg Thieme Verlag, 2021)
Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α -glucosidase in vitro. The present study investigated ex vivo ...