Imino-phospine palladium (II) and platinum (II) complexes: Synthesis, molecular structures and evaluation as antitumor agents
Date
2013Author
Motswainyana, William M.
Onani, Martin O.
Madiehe, Abram M.
Saibu, Morounke
Thovhogi, Ntevheleni
Lalancette, Roger A.
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The imino-phosphine ligands L1 and L2 were prepared via condensation reaction of 2-(diphenylphosphino)
benzaldehyde with substituted anilines and obtained in very good yields. An equimolar reaction of L1 and L2
with either PdCl2(cod) or PtCl2(cod) gave new palladium(II) and platinum(II) complexes 1–4. The compounds
were characterized by elemental analysis, IR, 1H and 31P NMR spectroscopy. The molecular structures of 2, 3
and 4 were confirmed by X-ray crystallography. All the three molecular structures crystallized in monoclinic
C2/c space system. The coordination geometry around the palladiumand platinumatoms in respective structures
exhibited distorted square planar geometry at the metal centers. The complexes were evaluated in vitro for their
cytotoxic activity against human breast (MCF-7) and human colon (HT-29) cancer cells, and they exhibited
growth inhibitory activities and selectivity that were superior to the standard compound cisplatin.