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MicroRNA-based regulation of Aurora A kinase in breast cancer
(Impact Journals, 2020)
The involvement of non-coding RNAs (ncRNAs) in cellular physiology and disease pathogenesis is becoming increasingly relevant in recent years specifically in cancer research. Breast cancer (BC) has become a health concern ...
Gene expression alterations and molecular analysis of CHEK1 in solid tumors
(MDPI, 2020)
Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ...
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
(MDPI, 2021)
Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ...
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
(SAGE, 2020)
The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ...
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
(Taylor and Francis, 2020)
The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ...
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)
The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a
diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral
drugs have played ...
Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries
(MDPI, 2023)
There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to
control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to
reduce pathogenic oral ...
Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts
(MDPI, 2023)
Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously
prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In
this study, water extracts from the ...