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PZQ Therapy: How close are we in the development of effective alternative anti-schistosomal drugs?
(Bentham Science Publishers, 2019)
Today schistosomiasis, caused mainly by the three major schistosome species (S.
mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a
rapid and swift rise globally, claiming ...
Forensic parameters and genetic structure based on Y-chromosome short tandem repeats in Lesotho populations
(Forensic Science International: Genetics Supplement Series, 2019)
Lesotho is a landlocked country with approximately 2.2 million inhabitants. Over 97% of the population is represented by the Southern Sotho people (Sotho-Tswana group), followed by a number of minorities mostly from the ...
UniQ-Typer ™ Y-10 genotyping in South African populations: novel alleles, sequence variation and allelic ladder updates
(Elsevier, 2019)
DNA profiling the male specific region on the Y-chromosome is fundamental to forensic practise. It is recognised as a powerful tool for sexual assault investigations for resolving the male DNA components, for familial ...
Structural analysis, molecular modelling and preliminary competition binding studies of AM-DAN as a NMDA receptor PCP-Site fluorescent ligand
(MDPI, 2019)
: Excitotoxicity related to the dysfunction of the N-methyl-d-aspartate receptor (NMDAR)
has been indicated to play an integral role in the pathophysiology of multiple disease states, including
neurodegenerative disorders ...
Exogenous p-coumaric acid improves salvia hispanica l. Seedling shoot growth
(MDPI Open Access Journals, 2019)
p-Coumaric acid (p-CA) belongs to a family of natural esters of hydroxycinnamic acid compounds that have been shown to modulate plant growth and metabolism. In this study, we investigated the effect of exogenous p-CA on ...
Forensic science international: genetics supplement series
(ScienceDirect, 2019)
We have designed a buffer for preservation of DNA in biological material at room temperature. In this work we evaluated the integrity of DNA from saliva, stored for 4 years and blood stored for 4 months at room temperature. ...
An in vitro study on the combination effect of metformin and n-acetyl cysteine against hyperglycaemia-induced cardiac damage
(MDPI - Publisher of Open Access Journals, 2019)
Chronic hyperglycaemia is a major risk factor for diabetes-induced cardiovascular dysfunction. In a hyperglycaemic state, excess production of reactive oxygen species (ROS), coupled with decreased levels of glutathione, ...
Genetic landscape of the mitochondrial DNA control region in South African populations
(ScienceDirect, 2019)
A high-quality dataset of the mitochondrial DNA control region sequences was generated with Sanger and next-generation sequencing. The study was aimed at characterizing the maternal genetic ancestry and analyzing the ...
In silico identification of micrornas as candidate Colorectal cancer biomarkers
(Sage Journals, 2019)
The involvement of microRNA in cancers plays a significant role in their pathogenesis. Specific expressions of these non-coding RNAs also serve as biomarkers for early colorectal cancer diagnosis, but their laboratory/molecular ...
Improved cellulase expression in diploid yeast strains enhanced consolidated bioprocessing of pretreated corn residues
(ScienceDirect, 2019)
In an effort to find a suitable genetic background for efficient cellulolytic secretion, genetically diverse strains were transformed to produce core fungal cellulases namely, β-glucosidase (BGLI), endoglucanase (EGII) and ...