Deletion of IL-4Rα signalling on B cells limits hyperresponsiveness depending on antigen-load.
| dc.contributor.author | Hadebe, Sabelo | |
| dc.contributor.author | Khumalo, Jermaine | |
| dc.contributor.author | Mangali, Sandisiwe | |
| dc.contributor.author | Mthembu, Nontobeko | |
| dc.contributor.author | Ndlovu, Hlumani | |
| dc.contributor.author | Scibiorek, Martyna | |
| dc.contributor.author | Ngomti, Amkele | |
| dc.contributor.author | Brombacher, Frank | |
| dc.date.accessioned | 2021-01-25T07:33:10Z | |
| dc.date.available | 2021-01-25T07:33:10Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | s: Hadebe S, Khumalo J, Mangali S, Mthembu N, Ndlovu H, Scibiorek M,Ngomti A, Kirstein F, Brombacher F, Deletion of IL-4Rα signalling on B cells limits hyperresponsivenessdepending on antigen-load., Journal of Allergy and Clinical Immunology (2021) | en_US |
| dc.identifier.uri | http://hdl.handle.net/10566/5735 | |
| dc.description.abstract | B cells play an important role in allergies through secretion of IgE. Interleukin 4 50 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine production, IgE 51 secretion and airway hyperresponsiveness (AHR). IL-4 activation of B cells is essential for 52 class-switching and contributes to the induction of B effector 2 (Be2) cells. The role of Be2 53 cells and signalling via IL-4Rα in B cells is not clearly defined. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | IL-4Rα | en_US |
| dc.subject | TH2 cells | en_US |
| dc.subject | B cells | en_US |
| dc.subject | germinal centre | en_US |
| dc.subject | T follicular helper cell | en_US |
| dc.subject | B effector 2 cells | en_US |
| dc.title | Deletion of IL-4Rα signalling on B cells limits hyperresponsiveness depending on antigen-load. | en_US |
| dc.type | Article | en_US |
