| dc.contributor.author | Egunlusi, A | |
| dc.contributor.author | Malan, S | |
| dc.contributor.author | Omoruyi, S | |
| dc.date.accessioned | 2021-09-01T15:28:28Z | |
| dc.date.available | 2021-09-01T15:28:28Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | Egunlusi, A.O.; Malan, S.F.; Omoruyi, S.I.; Ekpo, O.E.; Joubert, J. 4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential. Molecules 2020, 25, 4552. https://doi.org/10.3390/molecules25194552 | en_US |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.uri | http://hdl.handle.net/10566/6590 | |
| dc.description.abstract | The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor
overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among
the postulated processes involved in the development of neurodegenerative disorders. NGP1-01,
a polycyclic amine, has been shown to be neuroprotective through modulation of the NMDA
receptor and VGCC, and attenuation of MPP+-induced neurotoxicity. Recently, we reported on
the calcium modulating effects of tricycloundecene derivatives, structurally similar to NGP1-01,
on the NMDA receptor and VGCC of synaptoneurosomes. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | en_US |
| dc.subject | Neurodegenerative disorders | en_US |
| dc.subject | 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.subject | Neuroprotection | en_US |
| dc.subject | NMDA receptor | en_US |
| dc.title | 4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential | en_US |
| dc.type | Article | en_US |
