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The synergistic and neuroprotective effects of alcohol–antioxidant treatment on blood–brain barrier endothelial cells
(Wiley-Blackwell, 2020)
Background: Alcohol (EtOH) is reported to adversely affect one of the most crucial roles of the blood–brain barrier (BBB), the regulation of its permeability, thereby compromising the stability of the homeostatic environment ...
PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trial
(Springer Nature, 2020)
Purpose: To know which sperm selection technique, physiological intracytoplasmic sperm injection (PICSI) or magnetic-activated cell sorting (MACS), is better for the selection of sperm with abnormal sperm DNA fragmentation ...
Seminal oxidation–reduction potential levels are not influenced by the presence of leucocytospermia
(Wiley-Blackwell, 2020)
Oxidative stress (OS) is characterised by an excessive amount of reactive oxygen species (ROS) which negatively affect sperm functions. In this study, the influence of leucocytes on seminal oxidation–reduction potential ...
Is there a link between the pathogenic human Coronavirus envelope protein and immunopathology? A review of the literature
(Frontiers Media S.A., 2020)
Since the severe acute respiratory syndrome (SARS) outbreak in 2003, human
coronaviruses (hCoVs) have been identified as causative agents of severe acute
respiratory tract infections. Two more hCoV outbreaks have since ...
The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet
(Elsevier, 2020)
Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility. As excess adiposity causes ...
An insight into the mechanism of holamine- and funtumine-induced cell death in cancer cells
(MDPI, 2020)
Holamine and funtumine, steroidal alkaloids with strong and diverse pharmacological activities are commonly found in the Apocynaceae family of Holarrhena. The selective anti-proliferative and cell cycle arrest effects of ...
Silver nanoparticles stimulates spermatogenesis impairments and hematological alterations in testis and epididymis of Male rats
(MDPI, 2020)
The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free ...
Alkaloids: Therapeutic Potential against Human Coronaviruses
(MPDI, 2020)
Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity ...
Causes and consequences of sperm mitochondrial dysfunction
(Wiley-Blackwell, 2020)
Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis. Mitochondria have a significant contribution in ...
Ethnopharmacology, therapeutic properties and nutritional potentials of Carpobrotus edulis: A comprehensive review
(MPDI, 2020)
Carpobrotus edulis, formerly known as Mesembryanthemum edule L, belongs to the Aizoaceae
family of plants. It is a facultative halophytic invasive medicinal and edible succulent plant that is
native to South Africa and ...