Association among sperm chromatin condensation, sperm DNA fragmentation and 8-OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia
Abstract
The present study aimed to investigate the clinical role of standard sperm diagnosis
parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed on semen samples in infertile
men with oligoasthenoteratozoospermia (OAT). Thirty-two infertile and ten proven
fertile men were included in the study. Chromatin condensation sperm in infertile
men was significantly lower compared to the fertile men (p < 0.0001). Age, sperm
concentration, morphology and motility were significantly negatively correlated with
chromatin condensation (p < 0.05). However, no significant correlations among the
chromatin condensation, SDF and sperm DNA damage were detected in terms of 8-
OHdG concentration.