Browsing Research Articles (Medical Bioscience) by Title
Now showing items 178-197 of 256
-
Oxidative stress and assisted reproduction: A comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment
(MDPI, 2022)Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and antioxidants has been established as an important factor that can negatively affect the outcomes of assisted reproductive techniques ... -
Oxidative stress: A comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele
(Korean Society for Sexual Medicine and Andrology, 2021)Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. ... -
The paracrine effect of hypoxic and normoxic cancer secretion on the proliferation of brain endothelial cells (bend.3)
(MDPI, 2022): Background: This study aimed to investigate the disruption of cell cycle phases of bEnd.3 cells exposed to cancer paracrine secretion. Cancer cells have been reported to use the secretion of paracrine factors to ... -
The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy
(Springer, 2023)Capture myopathy (CM), which is associated with the capture and translocation of wildlife, is a life-threatening condition that causes noteworthy morbidity and mortality in captured animals. Such wildlife deaths have a ... -
PICSI vs. MACS for abnormal sperm DNA fragmentation ICSI cases: A prospective randomized trial
(Springer Nature, 2020)Purpose: To know which sperm selection technique, physiological intracytoplasmic sperm injection (PICSI) or magnetic-activated cell sorting (MACS), is better for the selection of sperm with abnormal sperm DNA fragmentation ... -
A plant-produced SARS-CoV-2 spike protein elicits heterologous immunity in hamsters
(Frontiers Media, 2023)Molecular farming of vaccines has been heralded as a cheap, safe and scalable production platform. In reality, however, differences in the plant biosynthetic machinery, compared to mammalian cells, can complicate the ... -
Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men
(Wiley, 2021)Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), ... -
A population model for the 2017/18 listeriosis outbreak in South Africa
(PLoS One, 2020-03-12)We introduce a compartmental model of ordinary differential equations for the population dynamics of listeriosis, and we derive a model for analysing a listeriosis outbreak. The model explicitly accommodates neonatal ... -
Potential for increasing folate contents of traditional African fermented sorghum gruel (Motoho) using presumptive probiotic lactic acid bacteria
(Elsevier, 2023)Folate deficiency is commonly observed in most developing countries. Lactic acid bacteria (LAB) fermentation of cereal-based foods could be an alternative to improving folate intake. This study evaluated the possibility ... -
Preliminary study on the effect of sugar cane (Saccharum officinarum) molasses on steroidogenesis in testicular cell cultures
(Academic Journals, 2010)Blackstrap molasses has been used for centuries in the preparation of food products and have also been used to treat numerous ailments such as high blood pressure, arthritis, ulcers, dermatitits, eczema, constipation, ... -
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies
(Springer, 2022)Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders of skeletal muscle causing weakness and disability. Utilizing single fibre contractility studies, we have previously shown that contractility is affected ... -
Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers
(American Society for Microbiology, 2004) -
Protein profiling in unlocking the basis of varicocele-associated infertility
(Blackwell Publishing Ltd, 2021)Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in ... -
Proteomic mechanisms of drug resistance in Candida cell membrane fractions
(International Association for Dental Research, 2014)INTRODUCTION: The African continent has the highest burden of HIV infection, accounting for approximately 65% of new infections globally. Oral candidiasis is a major cause of increased morbidity in HIV-infected individuals ... -
Proteomics and metabolomics — Current and future perspectives in clinical andrology
(Blackwell Publishing Ltd, 2021)Proteomics and metabolomics are emerging as promising tools to investigate the molecular mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in regulating the molecular pathways ... -
Psychosocial reintegration following traumatic spinal cord injury in South Africa: The influence of employment, injury characteristics and living situation
(The Journal of Spinal Cord Medicine,, 2022)1Department of Health and Rehabilitation Sciences, Division of Physiotherapy, Stellenbosch University, Cape Town, South Africa, 2Department of Physiotherapy, University of the Western Cape, Cape Town, South Africa Objectives: ... -
Quantification and identification of sperm subpopulations using computer-aided sperm analysis and species-specific cut-off values for swimming speed
(Taylor & Francis, 2013)Motility is an essential characteristic of all fl agellated spermatozoa and assessment of this parameter is one criterion for most semen or sperm evaluations. Computer-aided sperm analysis (CASA) can be used to measure ... -
Quantitative assessment of heavy metal effects on sperm function using computer‐aided sperm analysis and cytotoxicity assays
(Wiley, 2018)One known environmental risk factor impacting on human reproduction is heavy metal pollution. Although some metals (e.g., Cu, Se and Zn) have protective effects on the male reproductive system in low doses, heavy metals ... -
Quantitative sperm characteristics of Tankwa goats with special reference to hyperactivated motility
(South African Society for Animal Science, 2020)Computer-assisted semen analysis (CASA) is an automated and objective method of evaluating structural (e.g. morphology) and functional sperm parameters (e.g. motility and hyperactivation). Sperm hyperactivation is essential ... -
Quest for the best—a move to anatomical endoscopic enucleation of the prostate
(Wiley-Blackwell, 2020)The history of surgical enucleation for the treatment of lower urinary tract symptoms caused by benign prostatic enlargement dates back more than 100 years (Freyer, 1919). Open prostatec-tomy (OP) is an invasive procedure ...