Assessment of thermal and hydrolytic stabilities and aqueous solubility of artesunate for formulation studies

dc.contributor.author	Aucamp, M
dc.contributor.author	Bezuidenhout, J. W.
dc.contributor.author	Stieger, N
dc.contributor.author	Liebenberg, W
dc.contributor.author	Haynes, R. K
dc.date.accessioned	2023-03-28T12:45:25Z
dc.date.available	2023-03-28T12:45:25Z
dc.date.issued	2023
dc.identifier.citation	Bezuidenhout, J.W., Aucamp, M., Stieger, N., Liebenberg, W. and Haynes, R.K., 2023. Assessment of Thermal and Hydrolytic Stabilities and Aqueous Solubility of Artesunate for Formulation Studies. AAPS PharmSciTech, 24(1), p.33.	en_US
dc.identifier.uri	https://doi.org/10.1208/s12249-022-02490-8
dc.identifier.uri	http://hdl.handle.net/10566/8687
dc.description.abstract	For the purpose of establishing the optimum processing parameters and storage conditions associated with nanolipid formulations of the artemisinin derivative artesunate, it was necessary to evaluate the thermal stability and solubility profiles of artesunate in aqueous solutions at various temperatures and pH. The effect of increased temperature and humidity on artesunate was determined by storing samples of the raw material in a climate chamber for 3 months and analyzing these by an established HPLC method	en_US
dc.language.iso	en	en_US
dc.publisher	AAPS PharmSciTech	en_US
dc.subject	artesunate	en_US
dc.subject	decomposition	en_US
dc.subject	dihydroartemisinin	en_US
dc.subject	solubility	en_US
dc.subject	stability	en_US
dc.title	Assessment of thermal and hydrolytic stabilities and aqueous solubility of artesunate for formulation studies	en_US
dc.type	Article	en_US