A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients
dc.contributor.author | Michelle, Viljoen | |
dc.contributor.author | Iman, Moustafa | |
dc.contributor.author | Connolly, Catherine | |
dc.contributor.author | Anis, Malik | |
dc.date.accessioned | 2024-02-14T10:47:47Z | |
dc.date.available | 2024-02-14T10:47:47Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Moustafa, I., Connolly, C., Anis, M., Mustafa, H., Oosthuizen, F. and Viljoen, M., 2023. A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients. Journal of Oncology Pharmacy Practice, p.10781552231171114. | en_US |
dc.identifier.uri | http://dx.doi.org/10.1177/10781552231171114 | |
dc.identifier.uri | http://hdl.handle.net/10566/9304 | |
dc.description.abstract | Background: Doxorubicin induces acute and chronic cardiotoxicity. This study is aimed to evaluate the efficacy and safety of vitamin E and levocarnitine (EL) as cardioprotective agents against acute doxorubicin cardiotoxicity in female adult breast cancer patients. Methods: A prospective, randomized controlled study was conducted in patients treated with doxorubicin and cyclophosphamide (AC). Patients were randomly assigned to EL plus AC or AC alone for the duration of 4 cycles. Cardiac enzymes (B-type natriuretic peptide, creatine kinase, troponin I (Trop)) and cardiac events were monitored during treatment to evaluate the cardioprotective efficacy of EL. Results: Seventy-four patients were recruited and received four cycles of chemotherapy. The intervention group (n = 35) showed a significant reduction in both the B-type natriuretic peptide and creatine kinase cardiac enzymes compared to the control group (n = 39) | en_US |
dc.language.iso | en | en_US |
dc.publisher | SAGE Publications Ltd | en_US |
dc.subject | Adult cancer patients | en_US |
dc.subject | Cardiac toxicity | en_US |
dc.subject | Vdoxorubicin | en_US |
dc.subject | Levocarnitine | en_US |
dc.subject | Prophylaxis | en_US |
dc.title | A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients | en_US |
dc.type | Article | en_US |