Browsing by Author "Sharma, Rajan"
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Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis
Kapp, Erika; Joubert, Jacques; Sampson, Samantha, L; Malan, Sarel, F; Sharma, Rajan; Warner, Digby, F; Seldon, Ronnett; Jordaan, Audrey; de Vos, Margaretha (Advances in Pharmacological and Pharmaceutical Sciences, 2021-06)Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective ... -
Association between promoter methylation of MLH1 and MSH2 and reactive oxygen species in oligozoospermic men—A pilot study
Gunes, S.; Agarwal, A.; Henkel, Ralf; Sharma, Rajan; Esteves, S.C.; Aljowair, A.; Emirzeoglu, D.; Alkhani, A.; Pelegrini, L.; Joumah, A.; Sabanegh, E.; Mahmutoglu, A.M. (Wiley, 2017)MLH1 and MSH2 are important genes for DNA mismatch repair and crossing over during meiosis and are implicated in male infertility. Therefore, the methylation patterns of the DNA mismatch repair genes MLH1 and MSH2 in ... -
Calibration of redox potential in sperm wash media and evaluation of oxidation–reduction potential values in various assisted reproductive technology culture media using MiOXSYS system
Panner Selvam, M. K.; Henkel, Ralf; Sharma, Rajan; Agarwal, A. (Wiley, 2018)Oxidation–reduction potential describes the balance between the oxidants and antioxidants in fluids including semen. Various artificial culture media are used in andrology and IVF laboratories for sperm preparation and to ... -
Chemical composition and cosmeceutical potential of the essential oil of oncosiphon suffruticosum (L.) Källersjö
Adewinogo, Selena O.; Sharma, Rajan; Africa, Charlene W. J. (MDPI, 2021)The South African medicinal plant Oncosiphon suffruticosum (L.) Källersjö is an important remedy used to treat chronic, respiratory, and skin ailments. From the essential oil (EO) extracted by the hydrodistillation, ... -
Determination of seminal oxidation–reduction potential (ORP) as an easy and cost-effective clinical marker of male infertility
Agarwal, A.; Henkel, Ralf; Sharma, Rajan; Tadros, N.N.; Sabanegh, E. (Wiley, 2017)Oxidative stress (OS) is an important contributing factor to male infertility. While previous methods to measure seminal OS are time-consuming and limited to the use of freshly produced semen, oxidation reduction potential ... -
Human sperm handling in intracytoplasmic sperm injection processes: In vitro studies on mouse oocyte activation, embryo development competence and sperm oxidation–reduction potential
Roychoudhury, S.; Maldonado-Rosas, I.; Agarwal, A.; Esteves, S.C.; Henkel, Ralf; Sharma, Rajan (Wiley, 2018)Polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) are routinely used in handling spermatozoa for intracytoplasmic sperm injection (ICSI). As there are still concerns about possible adverse effects on the embryo, this ... -
In vitro alpha-glucosidase and alpha-amylase inhibitory activities and antioxidant capacity of helichrysum cymosum and helichrysum pandurifolium schrank constituents
Jadalla, Baraa M. I. S.; Moser, Justin J.; Sharma, Rajan (MDPI, 2022)Diabetes mellitus (DM) is a group of systemic metabolic disorders with a high rate of morbidity and mortality worldwide. Due to the detrimental side effects of the current treatment, there is a great need to develop more ... -
Microwave-assisted methods for the synthesis of pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines
Joubert, Jacques; Sharma, Rajan; Onani, Martin O.; Malan, Sarel F. (Elsevier, 2013)Efficient methodologies for the preparation of pentacyclo[5..4.0.02,6.03,10.05,9]undecane (PCU) amine derivatives are described via microwave-assisted synthesis. The obtained results revealed that microwave-assisted synthetic ... -
Synthesis and biological evaluations of NO-donating oxa- and aza-pentacycloundecane derivatives as potential neuroprotective candidates
Sharma, Rajan; Joubert, Jacques; Malan, Sarel F. (MDPI, 2018)In order to utilize the neuroprotective properties of polycyclic cage compounds, and explore the NO-donating ability of nitrophenyl groups, an array of compounds was synthesized where the different nitrophenyl groups ...