Browsing Faculty of Natural Sciences by Title
Now showing items 387-406 of 2567
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Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(Switzerland: MDPI AG, 2021)In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. ... -
Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(MPDI, 2021)In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. ... -
Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops
(BMC, 2016)Iron metabolism and regulation is an indispensable part of species survival, most importantly for blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron response ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
A conceptual model for the development and management of the Cape Flats aquifer, South Africa
(Water Research Commission, 2010)This paper provides an integrated approach to the analysis of the geological, hydrological and hydrogeological characteristics of the Cape Flats: a coastal plain sand formed within the mountains of the Cape Town metropolitan ... -
Conceptualising COVID-19’s impacts on household food security
(Springer, 2020)COVID-19 undermines food security both directly, by disrupting food systems, and indirectly, through the impacts of lockdowns on household incomes and physical access to food. COVID-19 and responses to the pandemic could ... -
Conductive composite biosensor system for electrochemical indinavir drug detection
(HINDAWI LTD, 2015)Indinavir is a protease inhibitor antiretroviral (ARV) drug, which forms part of the highly active antiretroviral therapy during the treatment of HIV/AIDS. Indinavir undergoes first-pass metabolism through the cytochrome ... -
Confidence intervals for the correlation between the gamma-ray burst peak energy and the associated supernova peak brightness
(Oxford University Press, 2009)A strong correlation between the gamma-ray burster peak energy and the peak luminosity of the associated supernova was discovered by Li for four GRBs. Despite the fact that the formal significance level of the correlation ... -
Connecting bridges across the digital divide
(ACM, 2004)Connecting people across the Digital Divide is as much a social effort as a technological one. We are developing a community-centered approach to learn how interaction techniques can compensate for poor communication across ... -
Consequences of using a smooth cosmic distance in a lumpy Universe. I.
(American Physical Society, 2022)How do we appropriately fit a model based on an idealised Friedmann-Lemaˆıtre Robertson-Walker spacetime to observations made from a single location in a lumpy Universe? We address this question for surveys that measure ... -
The conservation status and population decline of the African penguin deconstructed in space and time
(Wiley-Blackwell, 2020)Understanding changes in abundance is crucial for conservation, but population growth rates often vary over space and time. We use 40 years of count data (1979–2019) and Bayesian state-space models to assess the African ... -
Conservation status and threats for African reptiles
(Elsevier, 2016)The assimilation of information on taxonomy, distribution, basic ecology and conservation status of Africa's reptiles lags far behind that for most other continents. Many regions of mainland Africa are rarely surveyed, ... -
Conservation status of large branchiopods in the Western Cape, South Africa
(Springer Verlag, 2007)Temporary wetlands are an ecologically and economically important habitat in South Africa. They harbor large branchiopods, known to be flagship species of nonpermanent aquatic habitats, and sensitive to land use changes. ... -
Considerations for optimizing the photometric classification of supernovae from the Rubin observatory
(IOP Publishing, 2022)The Vera C. Rubin Observatory will increase the number of observed supernovae (SNe) by an order of magnitude; however, it is impossible to spectroscopically confirm the class for all SNe discovered. Thus, photometric ... -
Constraining primordial non-Gaussianity by combining next-generation galaxy and 21 cm intensity mapping surveys
(Institute for Ionics, 2023)Surveys of the matter distribution contain ‘fossil’ information on possible non-Gaussianity that is generated in the primordial universe. This primordial signal survives only on the largest scales where cosmic variance ... -
Constraining primordial non-gaussianity by combining next-generation galaxy and 21 cm intensity mapping surveys
(SpringerOpen, 2023)Surveys of the matter distribution contain ‘fossil’ information on possible non-Gaussianity that is generated in the primordialUniverse. This primordial signal survives only on the largest scales where cosmic variance ... -
Constraining the astrophysics and cosmology from 21 cm tomography using deep learning with the SKA
(Oxford University Press, 2020)Future Square Kilometre Array (SKA) surveys are expected to generate huge data sets of 21 cm maps on cosmological scales from the Epoch of Reionization. We assess the viability of exploiting machine learning techniques, ... -
Constraining the bright-end of the UV luminosity function for z ~ 7-9 galaxies: results from CANDELS/GOODS-South
(OUP, 2013)The recent Hubble Space Telescope near-infrared imaging with the Wide-Field Camera #3 (WFC3) of the GOODS-South field in the CANDELS program covering nearly 100 arcmin2, along with already existing Advanced Camera for ... -
Constraining the growth rate by combining multiple future surveys
(IOP Publishing, 2020)The growth rate of large-scale structure provides a powerful consistency test of the standard cosmological model and a probe of possible deviations from general relativity. We use a Fisher analysis to forecast constraints ... -
Constraining the intergalactic medium at z ≈ 9.1 using LOFAR Epoch of Reionization observations
(Advance access publications, 2020)We derive constraints on the thermal and ionization states of the intergalactic medium (IGM) at redshift ≈ 9.1 using new upper limits on the 21-cm power spectrum measured by the LOFAR radio telescope and a prior on the ...