Browsing Faculty of Natural Sciences by Subject "Covid-19"
Now showing items 1-20 of 39
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Challenges faced by African healthcare workers during the third wave of the pandemic
(Wiley, 2022)Africa experienced the third wave of the coronavirus disease in 2019, which caused an 18% rise in cases in most parts of the continent. As of January 2022, the region had an estimated 10.4 million cumulative cases and ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
Control and elimination in an SEIR model for the disease dynamics of Covid-19 with vaccination
(AIMS Press, 2023)COVID-19 has become a serious pandemic affecting many countries around the world since it was discovered in 2019. In this research, we present a compartmental model in ordinary differential equations for COVID-19 with ... -
Covid-19 among adults living with HIV: Correlates of mortality among public sector healthcare users in Western Cape, South Africa
(Wiley, 2023)Introduction: While a large proportion of people with HIV (PWH) have experienced SARS-CoV-2 infections, there is uncertainty about the role of HIV disease severity on COVID-19 outcomes, especially in lower-income settings. ... -
Covid-19 and cancer therapy: Interrelationships and management of cancer cases in the era of Covid-19
(Hindawi, 2021)'e COVID-19 global epidemic poses this generation’s biggest worldwide public health challenge probably since the 1918 influenza epidemic. Recent reports on two new variants have triggered a dramatic upsurge in research ... -
Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
(Public Library of Science, 2021)During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and ... -
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
(American Association for the Advancement of Science, 2022)Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the ... -
Face-to-face versus online-based lectures: A covid-19 induced study on assessments
(Frontiers Media, 2022)There is much debate regarding the impact of COVID-induced lockdown on the standard of assessments, mainly since students were assessed at home via an online assessment platform. Regular orthodox lectures and assessments ... -
The flexible, extended coil of the pdz-binding motif of the three deadly human coronavirus e proteins plays a role in pathogenicity
(MDPI, 2022)The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and SARS-CoV-2 have caused severe outbreaks. ... -
Functional landscape of SARS-CoV-2 cellular restriction
(Cell Press, 2021)A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular ... -
Human coronavirus NL63: A clinically important virus?
(Future Science Group, 2011)Respiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract ... -
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation supports ... -
Human coronavirus research: 20 years since the SARS-CoV outbreak
(Frontiers Media, 2022)This Editorial introduces 10 articles published in a Special Issue highlighting human coronavirus (hCoV) research on the twentieth anniversary of the outbreak of severe acute respiratory syndrome (SARS) in late 2002. ... -
The impact of Covid-19 vaccines on male semen parameters: A retrospective cohort study
(University of the Western Cape, 2023)The emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic necessitated the development of adequate vaccines. Despite vaccines being demonstrated to be safe and effective for preventing severe disease and death, ... -
Incidence and burden of injury at the Tokyo 2020 Paralympic Games held during the Covid-19 pandemic: A prospective cohort study of 66 045 athlete days
(British Journal of Sports Medicine, 2022)Objective To describe the epidemiology of injuries at the Tokyo 2020 Paralympic Games, including injuries sustained in the new sports of badminton and taekwondo. Methods Injury data were obtained daily via the established ... -
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
(Taylor and Francis, 2020)The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ... -
Leptin deficiency, caused by malnutrition, makes you susceptible to sars-cov-2 infection but could offer protection from severe Covid-19
(American Society for Microbiology, 2021)In much of the developing world, severe malnutrition is the most prevalent cause of immunodeficiency and affects up to 50% of the population in some impoverished communities. As yet, we do not know how severe acute ... -
‘Lockdown’: Digital and emergency elearning technologies—A student perspective
(MDPI, 2022)The COVID-19 pandemic and the subsequent emergency measures had a fundamental and disruptive impact on societies and, in particular, on the educational sector. The transition of the modality of educational delivery from ... -
Marburg virus disease amid Covid-19 in West Africa: An emerging and re-emerging zoonotic epidemic threat, future implications and way forward
(2023)Amid the coronavirus 2019 (COVID-19) pandemic, several African countries including Ghana and Equatorial Guinea have reported several zoonotic outbreaks. The COVID-19 pandemic has added more strain on the already ... -
Marburg virus disease outbreak amidst COVID-19 in the Republic of Guinea: A point of contention for the fragile health system?
(Elsevier, 2022)In August 2021, the Marburg virus disease (MVD) outbreak was confirmed amid the coronavirus disease 2019 (COVID-19) pandemic in the Republic of Guinea. This is the first time it is detected in Guinea and West Africa. Marburg ...