Browsing Faculty of Natural Sciences by Author "Mentor, Shireen"
Now showing items 1-6 of 6
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Are claudin-5 tight-junction proteins in the blood-brain barrier porous?
Fisher, David W.; Mentor, Shireen (Wolters Kluwer Health, 2020)The capillaries of the brain are particularly special, as they are not simply conduits for blood, but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic interstitium. Brain ... -
Exosomes form tunneling nanotubes (TUNTs) in the blood-brain barrier: A nano-anatomical perspective of barrier genesis
Mentor, Shireen; Fisher, David (Frontiers Media, 2022)The blood-brain barrier (BBB) is a robust interface between the blood and the central nervous system. Barrier type endothelium is able to limit paracellular (PC) movement, relegating molecular flux to the transendothel ... -
High-resolution insights into the in vitro developing blood-brain barrier: Novel morphological features of endothelial nanotube function
Mentor, Shireen; Fisher, David (Frontiers Media, 2021)High-resolution electron microscopy (HREM) imaging of the in vitro blood-brain barrier (BBB), is a promising modality for investigating the dynamic morphological interplay underpinning BBB development. The successful ... -
The Ism between endothelial cilia and endothelial nanotubules is an evolving concept in the genesis of the BBB
Mentor, Shireen; Fisher, David (MDPI, 2022)The blood–brain barrier (BBB) is fundamental in maintaining central nervous system (CNS) homeostasis by regulating the chemical environment of the underlying brain parenchyma. Brain endothelial cells (BECs) constitute ... -
Next generation precision medicine: Crispr-mediated genome editing for the treatment of neurodegenerative disorders
Mentor, Shireen (Springerlink, 2019)Despite significant advancements in the field of molecular neurobiology especially neuroinflammation and neurodegeneration, the highly complex molecular mechanisms underlying neurodegenerative diseases remain elusive. As ... -
The Role of Cytoskeletal Proteins in the Formation of a Functional In Vitro Blood-Brain Barrier Model
Mentor, Shireen; Makhathini, Khayelihle Brian; David, Fischer (MDPI, 2022)The brain capillary endothelium is highly regulatory, maintaining the chemical stability of the brain’s microenvironment. The role of cytoskeletal proteins in tethering nanotubules (TENTs) during barrier-genesis was ...