Browsing Faculty of Natural Sciences by Author "Pretorius, Ashley"
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Building HMM and molecular docking analysis for the sensitive detection of anti-viral pneumonia antimicrobial peptides (AMPs)
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Pretorius, Ashley (Nature Research, 2021)Pneumonia is the main reason for mortality among children under five years, causing 1.6 million deaths every year; late research has exhibited that mortality is increasing in the elderly. A few biomarkers used for its ... -
Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity
Pheiffer, Carmen; Dias, Stephanie; Pretorius, Ashley (Nature Research, 2022)The mechanisms that underlie exercise-induced adaptations in adipose tissue have not been elucidated, yet, accumulating studies suggest an important role for microRNAs (miRNAs). This study aimed to investigate miRNA ... -
DAMPD: a manually curated antimicrobial peptide database
Sundararajan, Vijayaraghava S.; Gabere, Musa N.; Pretorius, Ashley; Adam, Saleem; Christoffels, Alan; Minna, Lehvaslaiho; Archer, John A.C.; Bajic, Vladimir B. (Oxford University Press, 2012)The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates ... -
Dietary effects of antimicrobial peptides in therapeutics
Bakare, Olalekan Olanrewaju; Fadaka, Adewale Oluwaseun; Klein, Ashwil; Pretorius, Ashley (Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Functional prediction of candidate micrornas for CRC management using in silico approach
Fadaka, Adewale Oluwaseun; Pretorius, Ashley; Klein, Ashwil (MDPI, 2019)Approximately 30–50% of malignant growths can be prevented by avoiding risk factors and implementing evidence-based strategies. Colorectal cancer (CRC) accounted for the second most common cancer and the third most common ... -
Identification of biomarkers for the accurate and sensitive diagnosis of three bacterial pneumonia pathogens using in silico approaches
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Pretorius, Ashley (Springer Nature, 2020): Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A few ... -
In silico prediction of new antimicrobial peptides and proteins as druggable targets towards alternative anti-schistosomal therapy
Aruleba, Raphael Taiwo; Tincho, Marius Belmondo; Pretorius, Ashley (Elsevier, 2021)Schistosomiasis is a debilitating disease caused by a parasitic flatworm found in fresh- water. With the exponential increase in prevalence, Praziquantel (PZQ) remains the only effective treatment drug, however, resistance ... -
PZQ Therapy: How close are we in the development of effective alternative anti-schistosomal drugs?
Aruleba, Raphael Taiwo; Adekiya, Tayo Alex; Pretorius, Ashley (Bentham Science Publishers, 2019)Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni, S. haematobium and S. japonicum), has for many decades and still continues to be on a rapid and swift rise globally, claiming ...