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Direct inhibition of cyclooxygenase-2 enzyme by an extract of Harpagophytum procumbens, harpagoside and harpagide
(Academic Journals, 2011)
A methanolic extract of Harpagophytum procumbens as well as harpagoside and harpagide were tested
as direct inhibitors of cyclooxygenase-2 enzyme (COX-2). The H. procumbens extract demonstrated
direct inhibition (68%) of ...
Medicinal properties and in vitro biological activities of selected helichrysum species from South Africa: A review
(MDPI, 2021)
The genus Helichrysum Mill comprises hundreds of species that are mostly flowering
perennial shrubs. Some of these plants that belong to the Helichrysum species are used in traditional
medicine to treat cough, back pain, ...
Ethnopharmacology, therapeutic properties and nutritional potentials of Carpobrotus edulis: A comprehensive review
(MPDI, 2020)
Carpobrotus edulis, formerly known as Mesembryanthemum edule L, belongs to the Aizoaceae
family of plants. It is a facultative halophytic invasive medicinal and edible succulent plant that is
native to South Africa and ...
Crataegus monogyna and centella asiatica extracts as inhibitors of cathepsin s
(Horizon Research Publishing, 2022)
Cathepsin cysteine proteases such as
cathepsin S are responsible for the unfavorable and
irreversible dysregulation of extracellular matrix (ECM)
proteolysis found in cardiomyopathy, heart valve diseases
and atherosclerosis. ...
A post-market quality assessment of first-line, fixed-dose combination antiretrovirals in South Africa
(Journal of Applied Pharmaceutical Science, 2019)
South Africa has the world’s largest antiretroviral (ARV) program and despite having stringent upstream medicine’s
regulatory oversight, the post-market reassessment of ARV quality is prohibitively resource intensive. The ...
Steady‐state population pharmacokinetics of terizidone and itsmetabolite cycloserine in patients with drug‐resistanttuberculosis
(Wiley, 2019)
Despite terizidone being part of the second‐line recommended drugs fortreatment of drug‐resistant tuberculosis (DR‐TB), information on its pharmacokineticsis scarce. The aim of this study was to describe the steady‐state ...
Evaluation of the effects of Olea europaea L. subsp. africana (Mill.) P.S. Green (Oleaceae) leaf methanol extract against castor oil-induced diarrhoea in mice
(Oxford University Press, 2010)
Olea europaea L. subsp. africana (Mill.) P.S. Green is widely used in South
Africa by traditional medicine practitioners to treat diarrhoea. However, little is known
scientifically about this South African species in the ...
Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of ruta graveolens l. (rutaceae) in mice and rats
(African Networks Ethnomedicines, 2014)
Ruta graveolens has been used to treat toothache, earache, rheumatism and fever with little scientific evidence corroborating these uses. The leaf methanol extract of Ruta graveolens was evaluated for antinociceptive ...
The design and evaluation of ciprofloxacin-loaded nanoformulations using Ipomoea batatas starch nanoparticles
(SpringerOpen, 2023)
Starch nanoparticle derivatives are gaining popularity as drug delivery vehicles because of their biocompatibility,
better mechanical characteristics, heat stability properties, impediment qualities, permeability ...
Sub-analysis of cyp-guides data: Assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals
(Frontiers Media, 2022)
Minority groups are underrepresented in pharmacogenomics (PGx)
research. Recent sub-analysis of CYP-GUIDES showed reduced length of stay (LOS)
in depressed patients with CYP2D6 sub-functional status. Our primary objective ...