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Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells
(Elsevier, 2006)
The genome of the severe acute respiratory syndrome coronavirus encodes for eight accessory viral proteins with no known homologues in other
coronaviruses. One of these is the 3b protein, which is encoded by the second ...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
(National Academy of Sciences, 2003)
Saposin B is a small, nonenzymatic glycosphingolipid activator
protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids
from membranes, forming ...
Evaluation of protein purification techniques and effects of storage duration on lc-ms/ms analysis of archived ffpe human crc tissues
(Frontiers Media, 2021)
To elucidate cancer pathogenesis and its mechanisms at the molecular level, the collecting
and characterization of large individual patient tissue cohorts are required. Since most
pathology institutes routinely preserve ...
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
(Oxford University Press, 2018)
Triplet amino acids have successfully been included in feature selection to predict
human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is
curtailed due to experimental data not being ...
The flexible, extended coil of the pdz-binding motif of the three deadly human coronavirus e proteins plays a role in pathogenicity
(MDPI, 2022)
The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS-CoV, and
SARS-CoV-2 have caused severe outbreaks. ...
Identification of a novel protein with guanylyl cyclase activity in Arabidopsis thaliana
(Elsevier, 2003)
Guanylyl cyclases (GCs) catalyze the formation of the
second messenger guanosine 3 ,5 -cyclic monophos-
phate (cGMP) from guanosine 5 -triphosphate (GTP).
While many cGMP-mediated processes in plants have
been reported, ...
Protein interaction networks as metric spaces: A novel perspective on distribution of hubs
(BMC, 2014)
In the post-genomic era, a central and overarching question in the analysis of protein-protein
interaction networks continues to be whether biological characteristics and functions of proteins such as lethality,
physiological ...
The contribution of exon-skipping events on chromosome 22 to protein coding diversity
(Cold Spring Harbor Laboratory Press, 2001)
Completion of the human genome sequence provides evidence for a gene count with lower bound 30,000–40,000. Significant protein complexity may derive in part from multiple transcript isoforms. Recent EST based studies have ...
A simple, high-throughput modeling approach reveals insights into the mechanism of gametophytic self-incompatibility
(Nature Research, 2016)
Specificity in the GSI response results from the S-haplotype-specific molecular interaction of S-locus
F-box (SLF/SFB) and SRNase proteins in the self-incompatibility locus (S-locus). The answer to the
question of how ...
Identification of superior cellulase secretion phenotypes in haploids derived from natural Saccharomyces cerevisiae isolates
(Oxford University Press, 2019)
The yeast Saccharomyces cerevisiae is considered an important host for consolidated bioprocessing and the production of
high titres of recombinant cellulases is required for efficient hydrolysis of lignocellulosic substrates ...