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B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(AOSIS, 2018)
BACKGROUND: Altered immune mechanisms play a critical role in the pathogenesis of non-
Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive
T-cell activation, which can lead to increased ...
Structural rearrangements maintain the Glycan Shield of an HIV-1 envelope trimer after the loss of a glycan
(Nature Research, 2018)
The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a
critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected
from neutralisation. ...
Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing
(BioMed Central -The Open Access Publisher, 2013)
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well
documented while less is known about the role of historical viruses stored in the proviral DNA. The primary ...