Search
Now showing items 1-8 of 8
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Is human immunodeficiency virus (HIV) stage an independent risk factor for altering the periodontal status of HIV-positive patients? A South African study
(BMC, 2013)
The immunosuppresion in HIV patients makes them highly susceptible to microbial infections. The
aim of the study was to establish whether HIV stage (as depicted by CD4+ T lymphocyte counts) could
independently be associated ...
Optimal strategy for controlling the spread of HIV/AIDS disease: A case study of South Africa
(Taylor and Francis Group, 2012)
HIV/AIDS disease continues to spread alarmingly despite the huge amounts of resources invested infighting it. There is a need to integrate the series of control measures available to ensure a consistentreduction ...
Correlates of gender characteristics, health and empowerment of women in Ethiopia
(BMC, 2015)
The low status of women prevents them from recognizing and voicing their concerns about health
needs. This study aimed to examine the relationship between gender characteristics, health and empowerment of
women in an ...
Human coronavirus NL63: A clinically important virus?
(Future Science Group, 2011)
Respiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract ...
Modeling the dynamics of an epidemic under vaccination in two interacting populations
(Hindawi, 2012)
Mathematical modeling of the numerical evolution of infectious diseases has become an
important tool for disease control and eradication when possible. Much work has been done
on the problem of how a given population is ...
Causes and patterns of morbidity and mortality in Afghanistan: Joint estimation of multiple causes in the neonatal period
(Springer, 2014)
This paper focuses on investigating the leading cause(s) of death and preventable factors in Afghanistan,
using data from verbal autopsies of infant deaths. We are of the view that the presence
of a disease in a person ...