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Now showing items 1-10 of 19
A retrospective descriptive investigation of adult patients receiving third-line antiretroviral therapy in the North West province, South Africa
(Makerere University, 2020)
Greater access and prolonged exposure to ART may inevitably lead to more treatment failure and increase the need for third-line ART (TLART) in a resource-limited setting. Objective: To describe characteristics and resistance ...
Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
(Springer Nature, 2020)
Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ...
Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C integrase-dolutegravir binding
(Public Library of Science, 2020)
Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a ...
Validation of simple dichotomous self-report on prenatal alcohol and other drug use in women attending midwife obstetric units in the Cape Metropole, South Africa
(SAGE, 2020)
Background: This paper examines the degree of agreement among simple dichotomous self-report, validated screening results, and biochemical screening results of prenatal alcohol and other drug use among pregnant women. ...
Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
(MDPI, 2020)
: This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South
African adults living with hypertension. ...
Diverse genomoviruses representing twenty-nine species identified associated with plants
(Springer Nature, 2020)
Genomoviruses (family Genomoviridae) are circular single-stranded DNA viruses that have been mainly identifed through
metagenomics studies in a wide variety of samples from various environments. Here, we describe 98 genomes ...
Measurement and analysis of nuclear γ-ray production cross sections in proton interactions with Mg, Si, and Fe nuclei abundant in astrophysical sites over the incident energy range E = 30–66 MeV
(American Physical Society, 2020)
The modeling of nuclear
γ
-ray line emission induced by highly accelerated particles in astrophysical sites (e.g., solar flares, the gas and dust in the inner galaxy) and the comparison with observed emissions from these ...
Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa
(Public Library of Science, 2020)
Inappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was ...
An estuary ecosystem classification that encompasses biogeography and a high diversity of types in support of protection and management
(Taylor & Francis, 2020)
For nearly three decades, the Whitfield (1992) characterisation scheme served as a reference framework to type South African estuaries. We outline a revised ecosystem classification scheme that incorporates biogeographical ...
Using sap flow data to assess variations in water use and water status of apple orchards of varying age groups in the western cape province of South Africa
(Water Research Commission, 2020)
No accurate quantitative information currently exists on how water use of apple (Malus domestica) orchards varies from planting to full-bearing age, leading to poor irrigation and water allocation decision making. This ...