Browsing Research Articles (School of Pharmacy) by Title
Now showing items 65-84 of 151
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Evaluation of the antidiarrhoeal and antidiabetic activities of the leaf aqueous extract of Syzygium cordatum hoscht. ex C.Krauss (Mytraceae) in rodents
(Asian Network for Scientific Information, 2013)Syzygium cordatum Hoscht. ex C.Krauss is widely used by traditional medicine practitioners to treat many ailments including diarrhoea and diabetes. Despite the folklore use, little evidence can be found in literature to ... -
Evaluation of the effects of Olea europaea L. subsp. africana (Mill.) P.S. Green (Oleaceae) leaf methanol extract against castor oil-induced diarrhoea in mice
(Oxford University Press, 2010)Olea europaea L. subsp. africana (Mill.) P.S. Green is widely used in South Africa by traditional medicine practitioners to treat diarrhoea. However, little is known scientifically about this South African species in the ... -
Exploring practising pharmacy graduates’ views on improving the effectiveness of pharmacy education at the University of the Western Cape, South Africa
(HEALTH & MEDICAL PUBLISHING GROUP, 2019)South African health professional education institutions have a mandate to produce graduates who are able to address priority needs of the healthcare system and larger society. However, evidence of the effective use of ... -
Exploring the implications of a needs-based pharmacy education framework modelled on population health: Perspective from a developing country
(MDPI, 2019)Globally, health education reform is directing efforts to strengthen the health system through collaboration between health education and health services. However, collaborative efforts vary between developed and developing ... -
Exploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysis
(Springer Nature, 2020)Background: Drug–drug interactions (DDIs) cause significant morbidity and mortality, especially in patients with HIV with opportunistic infections such as tuberculosis. However, the literature on quantitative signal detection ... -
Fractions of Hoslundia opposita Vahl and hoslundin induced apoptosis in human cancer cells via mitochondrial-dependent reactive oxygen species (ROS) generation
(Elsevier, 2022)ancer remains one of the leading causalities of several morbidity and mortality with negative impact on global economy due to low workforce and management/treatment cost. A number of conventional therapies have been ... -
FTIR, dissolution and anti-viral activity of nevirapine co-crystals
(OMICS International, 2017)The study uses Fourier Transform Infrared (FTIR) spectroscopy to identify five Nevirapine (NV) co-crystals, determines the dissolution profile of the co-crystals and the antiviral activity comparative to pure NV. Hot ... -
Green synthesized saunps as a potential delivery platform for cytotoxic alkaloids
(MDPI, 2023)The use of natural products as chemotherapeutic agents is well established. However, many are associated with undesirable side effects, including high toxicity and instability. Previous reports on the cytotoxic activity ... -
The hidden curriculum of work-based learning for pharmacy students in public sector pharmacies in South Africa
(International Pharmaceutical Federation, 2017)BACKGROUND: The work-based learning environment encompasses a dynamic space where the implementation of theoretical knowledge and skills may prove to be at odds with routine service delivery practices, known as the ... -
“I just kept quiet”: Exploring equity in a service-learning programme
(International Association for Research on Service-Learning and Community Engagement (IARSLCE), 2016)Social justice underpins the sustainable development goal of health for all. In developing countries, social injustices are particularly severe and widespread, demanding critical and immediate attention. This article describes ... -
The implementation of a risk based assessment approach by the South African Health pProducts Regulatory Authority (SAHPRA)
(Springer, 2023)An extensive backlog of pending regulatory decisions is one of the major historical challenges that the South African Health Products Regulatory Authority (SAHPRA) inherited from the Medicine Control Council (MCC). Revising ... -
In vitro alpha-glucosidase and alpha-amylase inhibitory activities and antioxidant capacity of helichrysum cymosum and helichrysum pandurifolium schrank constituents
(MDPI, 2022)Diabetes mellitus (DM) is a group of systemic metabolic disorders with a high rate of morbidity and mortality worldwide. Due to the detrimental side effects of the current treatment, there is a great need to develop more ... -
The In vitro biological activity of biosynthesized silver nanoparticles produced using mangifera indica stem bark extract and properties of Its pharmaceutical gel formulation
(Springer, 2023)This study reports the production of silver nanoparticles using Mangifera indica stem bark (aqueous and methanol) extracts as capping agents and formulation of pharmaceutical gel loaded with the nanoparticles. The extracts ... -
In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes
(Obikeze, K. et al. (2023). In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes. Scientific African, 19, e01510. 10.1016/j.sciaf.2022.e01510, 2023)Leonotis leonurus extracts and compounds have been extensively studied for pharmacological effects. However, most of the diterpenes isolated from the plant have not been evaluated as possible contributors to the cardiovascular ... -
Inequalities in the prevalence of stunting, anemia and exclusive breastfeeding among African children
(BMC, 2022)Childhood stunting and anemia are on the increase in many resource-constrained settings, without a counter increase in proper feeding practices such as exclusive breastfeeding. The objective of this study was to explore ... -
Inorganic ions in leonotis leonurus extract do not explain changes in isolated Wistar rat heart function
(Open Access Science Research Publisher, 2011)Leonotis leonurus (L. leonurus) R. Br (Lamiaceae) is used by healers in South Africa. The present study was conducted to determine if the L. leonurus effect on isolated rat heart is due to ionic changes in the perfusion fluid. -
Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles
(Elsevier, 2022)Tuberculosis (TB) remains one of the deadliest communicable dis- eases caused by Mycobacterium tuberculosis (Mtb) since its discovery in the 1880s (Cambau and Drancourt, 2014; Singh et al., 2020). Over 1 billion mortalities ... -
An interesting case of carbamazepine-induced Stevens–Johnson Syndrome
(Springer, 2018)A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 ... -
Involvement of gamma aminobutyric acid in the anticonvulsant effect of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice
(Asian Network for Scientific Information, 2013)The possible involvement of gamma aminobutyric acid (GABA), in the anticonvulsant effect of Ruta graveolens L. was investigated by studying the effect of the leaf methanol extract against seizures elicited by either ... -
Iterative prophylactic treatment by hematin in two cases of recurrent disabling acute intern1ittent porphyria (AIP)
(Elsevier, 1989)Summary: Hematin is known as a useful drug in the treatment of acute intermittent porphyria (Al P) attacks. We have used it with success as an iterative prophylactic treatment in two cases of AIP with recurrent disabling ...