Browsing Research Articles (Biotechnology) by Author "Pearce, Brendon"
Now showing items 1-7 of 7
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Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality
Masilela, Charity Mandisa; Pearce, Brendon; Ongole, Joven Jebio (Springer Nature, 2020)Achieving the blood pressure treatment target in individuals with hypertension is a serious global health challenge. Furthermore, the actual burden of uncontrolled hypertension is poorly understood, especially in the ... -
Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
Masilela, Charity; Pearce, Brendon; Ongole, Joven J.; Adeniyi, Oladele V.; Johnson, Rabia; Benjeddou, Mongi (NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ... -
Factors associated with glycemic control among South African adult residents of Mkhondo municipality living with diabetes mellitus
Masilela, Charity; Pearce, Brendon; Ongole, Joven Jebio (Lippincott, Williams & Wilkins, 2020)This study examines the rate and the influencing factors of glycemic control among adult residents living with DM in Mkhondo Municipality of South Africa. In this cross-sectional study, 157 individuals attending care for ... -
Genetic association of solute carrier transporter gene variants with metformin response
Pearce, Brendon; brahams-October, Z; Xhakaza, L (Balkan Journal of Medical Genetics, 2021)Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood glucose levels and is influenced by both genetic and environmental factors. It is treated with various classes of oral antidiabetic ... -
Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa
Jacobs, Clifford; Pearce, Brendon; Du Plessis, Mornè (Brazilian Society of Genetics, 2014)Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs. Genetic polymorphisms ... -
Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
Masilela, Charity Mandisa; Pearce, Brendon; Ongole, Joven Jebio (MDPI, 2020): This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South African adults living with hypertension. ... -
The potential of chalcone-capped gold nanoparticles for the management of diabetes mellitus
Pearce, Brendon; Benjeddou, Mongi; Botha, Subelia; Omolaja, Akinfenwa, A; Omuruyia, Sylvester, I; Badmus, Jelili, A; Ismail, Enas; Marnewick, Jeanine; Ekpob, Okobi, E; Hussein, Ahmed, A (Surfaces and Interfaces, 2021-08)Searching for new natural bioactive capping agents represent an urgent priority in the green synthesis of metal nanoparticles. Additionaly, the biosaftey of metal nanparticles is a major concern especially in medical ...